Drospirenone EP Impurity K CAS 889652-31-7
| CAS No. | 889652-31-7 |
| Molecular Formula | C24H30O3 |
| Molecular Weight | 366.49 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Drospirenone EP Impurity K is closely related to a steroid core, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Drospirenone EP Impurity K (CAS 889652-31-7, C24H30O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a steroid core, a hydroxyl group, an ether linkage, Drospirenone EP Impurity K is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 366.49 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C24H30O3 |
| Molecular Weight | 366.49 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
Related Drospirenone Standards
- Drospirenone (CAS 67392-87-4)
- Drospirenone EP Impurity E (CAS 90457-65-1)
- Drospirenone Impurity 14 (CAS CATO-C4X-162414)
- Drospirenone EP Impurity F (CAS CATO-C4X-16245)
- Drospirenone EP Impurity I (CAS 2896199-04-3)
- Drospirenone Impurity N3 (CAS 863329-71-9)
- Drospirenone-20,20,21,21-d4 (CAS 2376035-94-6)
- Drospirenone EP Impurity A (CAS 67372-68-3)
Recommended Standards
- Tert-Butyl ((1-Benzhydrylazetidin-3-Yl)Methyl)(Methyl)Carbamate (CAS 1064048-70-9)
- 2-((3,5-Dimethoxybenzyl)thio)-5-(4-methylpiperazin-1-yl)-1,3,4-thiadiazole (CAS 1105220-89-0)
- Ketoprofen 2-Ethylhexyl Ester (CAS CATO-C4X-147169)
- 2-(tert-Butyl)-1-(1H-imidazol-1-yl)pentan-1-one (CAS 110577-44-1)
- Piperazine Impurity 17 (CAS CATO-C4X-242717)
- Pazopanib Impurity 6 (CAS 1226499-98-4)
- Ixazomib Impurity 60 (CAS CATO-C4X-126760)
- 4-Amino-N-isobutyl-1,2,5-oxadiazole-3-carboxamide (CAS 405278-58-2)
- 3-((Butyryloxy)methyl) 5-methyl 4-(2,4-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate (Clevidipine Impurity) (CAS 2458150-58-6)
- N-(2-(6-Oxo-1,6-dihydropyridazin-3-yl)phenyl)thiophene-2-carboxamide (CAS 1428357-19-0)
- Cbz-N-Me-Thr-OH (CAS 253595-72-1)
- 1-(4-Fluorophenyl)-2-(2-(methylthio)pyrimidin-4-yl)ethanone (CAS 217661-99-9)
- 2-(Cyclopropanecarboxamido)-5-iodobenzoic acid (CAS 433966-91-7)
- RGD-targeted Proapoptotic Peptide trifluoroacetate salt (CAS 2243207-09-0)
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