Drospirenone EP Impurity E CAS 90457-65-1
| CAS No. | 90457-65-1 |
| Molecular Formula | C24H30O3 |
| Molecular Weight | 366.49 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 366.49 g/mol gives Drospirenone EP Impurity E distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Drospirenone EP Impurity E (CAS 90457-65-1) is a certified pharmaceutical impurity reference standard with the molecular formula C24H30O3 and a molecular weight of 366.49 g/mol.
Owing to a steroid core, a hydroxyl group, an ether linkage, Drospirenone EP Impurity E is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 366.49 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Drospirenone EP Impurity E meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C24H30O3 |
| Molecular Weight | 366.49 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1982 |
Related Drospirenone Standards
- Drospirenone (CAS 67392-87-4)
- Drospirenone EP Impurity K (CAS 889652-31-7)
- Drospirenone Impurity 14 (CAS CATO-C4X-162414)
- Drospirenone EP Impurity F (CAS CATO-C4X-16245)
- Drospirenone EP Impurity I (CAS 2896199-04-3)
- Drospirenone Impurity N3 (CAS 863329-71-9)
- Drospirenone-20,20,21,21-d4 (CAS 2376035-94-6)
- Drospirenone EP Impurity A (CAS 67372-68-3)
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