Rosuvastatin Impurity 136 CAS 890028-66-7
| CAS No. | 890028-66-7 |
| Molecular Formula | C18H20FN3O3S |
| Molecular Weight | 377.43 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Rosuvastatin Impurity 136 (CAS 890028-66-7, C18H20FN3O3S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Rosuvastatin Impurity 136 (C18H20FN3O3S) contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H20FN3O3S |
| Molecular Weight | 377.43 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Rosuvastatin Standards
- Rosuvastatin Impurity 79 (CAS 1326303-05-2)
- Rosuvastatin Impurity 188 (CAS CATO-C4X-1169188)
- Rosuvastatin Impurity 189 (CAS CATO-C4X-1169189)
- Rosuvastatin Impurity 190 (CAS CATO-C4X-1169190)
- Rosuvastatin Impurity 19 (CAS 1035595-71-1)
- Rosuvastatin Impurity 25 (CAS 289042-11-1)
- Rosuvastatin Impurity 172 (CAS 1469771-46-7)
- Rosuvastatin Impurity 99 (CAS CATO-C4X-116999)
Recommended Standards
- Vonoprazan Impurity 281 (CAS 3058423-29-0)
- Terbutaline impurity 86 (CAS CATO-C4X-118386)
- tert-Butyl5-(methoxymethoxy)-4-oxospiro[chroman-2,4-piperidine]-1-carboxylate (CAS 911227-80-0)
- Roxatidine Impurity 75 (CAS CATO-C4X-121375)
- Sunitinib Impurity 31 (CAS 342641-94-5)
- Bumetanide Impurity 120 (CAS CATO-C4X-1986120)
- Duloxetine EP Impurity D (CAS 90-15-3)
- 3,5-Dichloro-n-hydroxybenzamide (CAS 18540-38-0)
- Sitagliptin Impurity 107 (CAS 89124-06-1)
- 2-(Benzyloxy)benzyl acetate (CAS 1073234-31-7)
- Flibanserin Hydrochloride (CAS 147359-76-0)
- Ethyl 3-chloro-2-oxo-2H-pyran-5-carboxylate (CAS 126703-76-2)
- Eribulin mesylate intermediate (CAS 157322-83-3)
- Anxiety Peptide (CAS 95237-86-8)
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