卡非佐米杂质8 CAS 890660-08-9
| CAS No. | 890660-08-9 |
| Molecular Formula | C27H35N3O5 |
| Molecular Weight | 481.58 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, 卡非佐米杂质8 (CAS 890660-08-9, C27H35N3O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
卡非佐米杂质8 (C27H35N3O5) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C27H35N3O5 |
| Molecular Weight | 481.58 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Nitrogen Atoms | 3 |
Recommended Standards
- 7-Benzyloxy-1-(4-benzyloxy-3-hydroxybenzyl)-6-methoxy -1,2,3,4-tetrahydroisoquinoline (CAS 62744-15-4)
- Repaglinide Impurity 25 (CAS CATO-C4X-118625)
- N-[2-[3-Methoxy-4-(phenylmethoxy)phenyl]ethyl]-4-(phenylmethoxy)benzeneacetamide (CAS 132257-11-5)
- Bevantolol Impurity 34 (CAS CATO-C4X-241134)
- Cariprazine Impurity 43 (CAS 1092822-52-0)
- Lomefloxacin Impurity 10 （HCl） (CAS CATO-C4X-207310)
- Linagliptin Impurity 113 (CAS 2803369-89-1)
- N,N-diisobutylpiperidine-2-carboxamide (CAS 1218686-48-6)
- (4,5-Dimethoxybenzo[1,2-b:6,5-b']dithiophene-2,7-diyl)bis(tributylstannane) (CAS 1609590-14-8)
- 6-[(2-tert-Butoxycarbonylaminoethyl)amino]-7-chloro-1-cyclopropyl-1,4-dihydro-4-oxo-quinoline-3-carboxylic Acid (CAS 528851-37-8)
- rac N,N-Dimethyl Amphetamine-d6 Hydrochloride (CAS 1346597-92-9)
- Rhein acyl-β-D-glucuronide (CAS 190605-03-9)
- Formosanin C (CAS 50773-42-7)
- Semaglutide impurity 249 (CAS CATO-C4X-2226249)
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