4-(4-Fluorobenzenesulfonyl)-2-(4-fluorophenyl)-5-(propane-1-sulfonyl)-1,3-oxazole CAS 891021-50-4
| CAS No. | 891021-50-4 |
| Molecular Formula | C18H15F2NO5S2 |
| Molecular Weight | 427.44 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
4-(4-Fluorobenzenesulfonyl)-2-(4-fluorophenyl)-5-(propane-1-sulfonyl)-1,3-oxazole (CAS 891021-50-4), molecular formula C18H15F2NO5S2 and molecular weight 427.44 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4-(4-Fluorobenzenesulfonyl)-2-(4-fluorophenyl)-5-(propane-1-sulfonyl)-1,3-oxazole (C18H15F2NO5S2) is characterized by a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C18H15F2NO5S2 |
| Molecular Weight | 427.44 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 2 |
Related Fluorobenzenesulfonyl Standards
- N-[4-(4-Fluorobenzenesulfonyl)phenyl]-3-(trifluoromethyl)benzamide (CAS 339030-34-1)
- Methyl 2-[(4-fluorobenzenesulfonyl)oxy]-5-iodobenzoate (CAS 297150-19-7)
- [5-(4-Fluorobenzenesulfonyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl 2-chloroacetate (CAS 318469-42-0)
- 3-(4-Fluorobenzenesulfonyl)-2-hydroxy-2-methyl-N-[4-(trifluoromethyl)phenyl]propanamide (CAS 338956-16-4)
- 4-[4-(4-fluorobenzenesulfonyl)piperazin-1-yl]-1h-indole (CAS 256458-65-8)
- (2S)-2-{[1-(4-fluorobenzenesulfonyl)piperidin-3-yl]formamido}propanoic acid (CAS 956380-74-8)
- Methyl 3-[(4-fluorobenzenesulfonyl)oxy]-4-nitrobenzoate (CAS 297150-07-3)
- Butyl 4-[(4-fluorobenzenesulfonyl)oxy]benzoate (CAS 331462-37-4)
Recommended Standards
- (S)-(2-Methyl-4-((4-(trifluoromethyl)phenyl)sulfonyl)piperazin-1-yl)(2-methylpyridin-3-yl)methanone hydrochloride (CAS 1204535-44-3)
- 5-(Biphenyl-2-yloxymethyl)-4-(2-trifluoromethyl-phenyl)-4H-[1,2,4]triazole-3-thiol (CAS 722464-17-7)
- Avatrombopag Impurity 77 (CAS CATO-C4X-223477)
- EzetimiBe Impurity 19 (CAS 1391053-63-6)
- (R)-2-Boc-1,2,3,4-tetrahydroisoquinoline-1-carboxylic Acid (CAS 151004-96-5)
- 2-(3-Chloro-4-fluorophenyl)pyrimidine-5-carboxylic acid (CAS 1405161-03-6)
- (5,5-Dimethylpyrrolidin-2-yl)methanol (CAS 1248551-44-1)
- 2,4-dichloro-6-fluoro-quinoline (CAS 406204-74-8)
- (S)-2-(1-(2-((tert-Butoxycarbonyl)amino)acetyl)pyrrolidine-2-carboxamido)acetic acid (CAS 66143-41-7)
- 3-(Difluoromethyl)-6-formyl-2-iodoisonicotinonitrile (CAS 1805388-52-6)
- 3-(3-(2H-Benzo[d][1,2,3]triazol-2-yl)-5-(tert-butyl)-4-hydroxyphenyl)propanoic acid (CAS 84268-36-0)
- 4-Methoxy-2-(trifluoromethyl)-1H-indole (CAS 1416372-46-7)
- 06:0 PA 1,2-dicaproyl-sn-glycero-3-phosphate (sodium salt) 1,2-dihexanoyl-sn-glycero-3-phosphate (sodium salt) 321883-53-8 PA(6:0/6:0) (CAS 321883-53-8)
- Des-[Gly]31-Semaglutide(x TFA Salt) (CAS 873874-39-6(free base))
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