EzetimiBe Impurity 19 CAS 1391053-63-6
| CAS No. | 1391053-63-6 |
| Molecular Formula | C24H23F2NO4 |
| Molecular Weight | 427.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, EzetimiBe Impurity 19 (CAS 1391053-63-6, C24H23F2NO4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, EzetimiBe Impurity 19 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes ā including a molecular weight of 427.44 g/mol ā guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), EzetimiBe Impurity 19 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C24H23F2NO4 |
| Molecular Weight | 427.44 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related EzetimiBe Standards
- Ezetimibe Impurity 88 (CAS 1618657-29-6)
- Ezetimibe Impurity 32 (CAS 1700622-08-7)
- Ezetimibe Impurity 142 (CAS CATO-C4X-1098142)
- Ezetimibe Impurity 70 (CAS 937636-63-0)
- Ezetimibe Impurity 18 (CAS 204589-80-0)
- Ezetimibe Impurity 44 (CAS 204589-82-2)
- Ezetimibe Impurity 117 (CAS 1013025-04-1)
- Ezetimibe Impurity 106 (CAS CATO-C4X-1098106)
Recommended Standards
- 5-(Biphenyl-2-yloxymethyl)-4-(2-trifluoromethyl-phenyl)-4H-[1,2,4]triazole-3-thiol (CAS 722464-17-7)
- 4-(4-Fluorobenzenesulfonyl)-2-(4-fluorophenyl)-5-(propane-1-sulfonyl)-1,3-oxazole (CAS 891021-50-4)
- 2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(1H-pyrrolo[2,3-Ī²]pyridin-3-yl)propanoic acid (CAS 1219143-85-7)
- (S)-(2-Methyl-4-((4-(trifluoromethyl)phenyl)sulfonyl)piperazin-1-yl)(2-methylpyridin-3-yl)methanone hydrochloride (CAS 1204535-44-3)
- Ilaprazole Impurity 147 (CAS CATO-C4X-1130147)
- Tedizolid Impurity 44 (CAS 92159-87-0)
- Oseltamivir Impurity 134 (CAS CATO-C4X-1720134)
- Sitagliptin Impurity 118 (CAS 1261633-32-2)
- Acetyl 2-[(2-Formamide-1,6-dihydro-6-chloro-9H-purin-9yl)methoxy]ethyl Ester (CAS 1346598-89-7)
- n-(4-(Cyclopentylthio)phenyl)propionamide (CAS 1197613-57-2)
- (R)-3-Hydroxy-7-methyl-oct-6-enoic acid methyl ester (CAS 87894-26-6)
- (4-(Benzylcarbamoyl)-3-fluorophenyl)boronic acid (CAS 874289-19-7)
- 4-(Cyanomethyl)phenyl 4-methylbenzenesulfonate (CAS 175135-39-4)
- Peptide Impurity 64 (CAS CATO-CPTD788964)
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