Famotidine impurity 72 CAS 89167-37-3
| CAS No. | 89167-37-3 |
| Molecular Formula | C25H24FNO4 |
| Molecular Weight | 421.46 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Famotidine impurity 72 is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Famotidine impurity 72 (CAS 89167-37-3, C25H24FNO4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Famotidine impurity 72 (C25H24FNO4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 14.0, corresponding to approximately 14 ring(s) or double-bond equivalent(s). With a molecular weight of 421.46 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Famotidine impurity 72 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C25H24FNO4 |
| Molecular Weight | 421.46 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1982 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Famotidine Standards
- Famotidine impurity 64 (CAS CATO-C4X-139264)
- Famotidine EP Impurity E (CAS 129083-44-9)
- Famotidine Impurity 56 (CAS CATO-C4X-139256)
- Famotidine Impurity 57 (CAS CATO-C4X-139257)
- Famotidine impurity 59 (CAS CATO-C4X-139259)
- Famotidine EP Impurity I (CAS 1020719-36-1)
- Famotidine Impurity 11 (CAS 90237-03-9)
- Famotidine Impurity 32 (CAS 154754-59-3)
Recommended Standards
- Pitavastatin Impurity 7 (CAS 769908-13-6)
- Vericiguat Impurity 77 (CAS CATO-C4X-289677)
- Pitavastatin Impurity 60 (CAS CATO-C4X-103760)
- N-(3,4-dimethoxyphenyl)-2-(4-oxo-7-phenylthieno[3,2-d]pyrimidin-3(4H)-yl)acetamide (CAS 1105207-58-6)
- Salbutamol Impurity 173 (CAS CATO-C4X-1176173)
- Olmesartan Impurity 35 (CAS CATO-C4X-109735)
- Lifitegrast Impurity 149 (CAS CATO-C4X-2409149)
- 4-(3-Bromophenoxy)benzoic acid (CAS 347173-46-0)
- 6-Chloro-2-(3,4-dichlorophenyl)-3-hydroxy-3,4-dihydroquinazolin-4-one (CAS 338412-56-9)
- 3-[(2-chloroacetamido)methyl]-N-cyclopropylbenzamide (CAS 1311317-71-1)
- Rhenium, pentacarbonyl[(triphenylphosphine)gold]-, (Au-Re) (CAS 20519-22-6)
- Manganese ammonium phosphate (CAS 13446-31-6)
- Compstatin control peptide (CAS 301544-78-5)
- Peptide Impurity 64 (CAS CATO-CPTD788964)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com