Lifitegrast Impurity 149 CAS CATO-C4X-2409149
| CAS No. | CATO-C4X-2409149 |
| Molecular Formula | C10H12ClNO2 |
| Molecular Weight | 213.66 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Lifitegrast Impurity 149 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Lifitegrast Impurity 149 (CAS CATO-C4X-2409149) is a certified pharmaceutical impurity reference standard with the molecular formula C10H12ClNO2 and a molecular weight of 213.66 g/mol.
The molecular framework of Lifitegrast Impurity 149 (C10H12ClNO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C10H12ClNO2 |
| Molecular Weight | 213.66 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Lifitegrast Standards
- Lifitegrast Impurity 108 (CAS CATO-C4X-2409108)
- Lifitegrast Impurity 109 (CAS CATO-C4X-2409109)
- Lifitegrast Impurity N68 (CAS 89315-56-0)
- Lifitegrast Impurity 62 (CAS CATO-C4X-240962)
- Lifitegrast Impurity 110 (CAS 2091680-73-6)
- Lifitegrast Impurity 19 (CAS 1289646-90-7)
- Lifitegrast Impurity 27 (CAS 14046-52-7)
- Lifitegrast Impurity N99 (CAS 1195655-47-0)
Recommended Standards
- Phenacetin Impurity 4 (CAS 53689-25-1)
- Procaine Impurity 8 (CAS 59265-81-5)
- Proparacaine Impurity 19 (CAS 343773-15-9)
- Baclofen (CAS 1134-47-0)
- Apixaban Impurity 29 (CAS CATO-C4X-108829)
- Dorzolamide Impurity 13 (CAS 897657-78-2)
- Semaglutide Impurity 145 (CAS CATO-C4X-2226145)
- Eravacycline Impurity 7(TP-498） (CAS CATO-C4X-29387)
- 3-(2-Bromo-4-methylphenyl)pentan-3-ol (CAS 1583297-71-5)
- 1-(3-Chlorobenzyl)-1,2-dihydro-3h-1,2,4-triazol-3-imine (CAS 832739-72-7)
- 6-(Furan-2-yl)-2-hydroxy-4-(thiophen-2-yl)nicotinonitrile (CAS 111121-81-4)
- 3,4-Dihydroquinolin-1(2H)-amine (CAS 5825-45-6)
- 1-(Benzo[d][1,3]dioxol-5-yl)-2-(methylthio)ethan-1-one (CAS 77263-37-7)
- Tau Peptide (298-312) trifluoroacetate salt (CAS 330456-47-8)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com