2-((1R,4r)-4-(4-(5-((3,4-difluorophenyl)amino)-1,3,4-oxadiazole-2-carboxamido)phenyl)cyclohexyl)acetic acid CAS 892489-52-0

Purity 97%+In StockPharmaceutical Standards
CAS No.892489-52-0
Molecular FormulaC23H22F2N4O4
Molecular Weight456.44 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

2-((1R,4r)-4-(4-(5-((3,4-difluorophenyl)amino)-1,3,4-oxadiazole-2-carboxamido)phenyl)cyclohexyl)acetic acid CAS 892489-52-0 chemical structure

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-((1R,4r)-4-(4-(5-((3,4-difluorophenyl)amino)-1,3,4-oxadiazole-2-carboxamido)phenyl)cyclohexyl)acetic acid.

2-((1R,4r)-4-(4-(5-((3,4-difluorophenyl)amino)-1,3,4-oxadiazole-2-carboxamido)phenyl)cyclohexyl)acetic acid (CAS 892489-52-0) is a high-purity analytical reference standard with the molecular formula C23H22F2N4O4 and a molecular weight of 456.44 g/mol.

The molecular framework of 2-((1R,4r)-4-(4-(5-((3,4-difluorophenyl)amino)-1,3,4-oxadiazole-2-carboxamido)phenyl)cyclohexyl)acetic acid (C23H22F2N4O4) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

As a certified reference material (CRM), 2-((1R,4r)-4-(4-(5-((3,4-difluorophenyl)amino)-1,3,4-oxadiazole-2-carboxamido)phenyl)cyclohexyl)acetic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC23H22F2N4O4
Molecular Weight456.44 g/mol
AppearancePale yellow to yellow crystalline powder. (slight halide-like odor, low volatility)
Purity97%+
StorageStore in a cool place (≤25°C), protect from light, keep sealed and dry
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)14.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1987
Halogen ContentF-containing
Nitrogen Atoms4

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