Famotidine EP Impurity B CAS 89268-62-2
| CAS No. | 89268-62-2 |
| Molecular Formula | C16H23N11O2S5 |
| Molecular Weight | 561.75 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Famotidine EP Impurity B (C16H23N11O2S5) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Famotidine EP Impurity B (CAS 89268-62-2) is a certified pharmaceutical impurity reference standard with the molecular formula C16H23N11O2S5 and a molecular weight of 561.75 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H23N11O2S5 |
| Molecular Weight | 561.75 g/mol |
| Purity | >80% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1982 |
| Nitrogen Atoms | 11 |
| Sulfur Atoms | 5 |
Related Famotidine Standards
- Famotidine Impurity 47 (CAS CATO-C4X-139247)
- Famotidine Impurity 48 (CAS CATO-C4X-139248)
- Famotidine Impurity 77 (CAS CATO-C4X-139277)
- Famotidine impurity 64 (CAS CATO-C4X-139264)
- Famotidine impurity 72 (CAS 89167-37-3)
- Famotidine EP Impurity E (CAS 129083-44-9)
- Famotidine Impurity 56 (CAS CATO-C4X-139256)
- Famotidine Impurity 57 (CAS CATO-C4X-139257)
Recommended Standards
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- (S)-2-((Bis(tetradecyloxy)phosphoryl)amino)propanoic acid (CAS 830320-80-4)
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- Eltrombopag impurity 148 (CAS CATO-C4X-1198148)
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- 4-(3-Pyridinyl)benzaldehyde (CAS 127406-55-7)
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