Eltrombopag impurity 148 CAS CATO-C4X-1198148
| CAS No. | CATO-C4X-1198148 |
| Molecular Formula | C25H21ClN4O5 |
| Molecular Weight | 492.91 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Eltrombopag impurity 148.
CATO supplies Eltrombopag impurity 148 (CAS CATO-C4X-1198148), a pharmacopoeial impurity reference standard (molecular formula C25H21ClN4O5, MW 492.91 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Eltrombopag impurity 148 (C25H21ClN4O5) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Eltrombopag impurity 148 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C25H21ClN4O5 |
| Molecular Weight | 492.91 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 17.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Eltrombopag Standards
- Eltrombopag Impurity 80 (CAS CATO-C4X-119880)
- Eltrombopag Impurity 27 (CAS CATO-C4X-119827)
- Eltrombopag Impurity 29 (CAS CATO-C4X-119829)
- Eltrombopag Impurity 97 (CAS CATO-C4X-119897)
- Eltrombopag Impurity 23 (CAS CATO-C4X-119823)
- Eltrombopag Impurity 25 (CAS CATO-C4X-119825)
- Eltrombopag Impurity 12 (CAS 376592-56-2)
- Eltrombopag impurity 146 (CAS CATO-C4X-1198146)
Recommended Standards
- N-[(4-Chlorophenyl)methyl]-1-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide (CAS 321848-21-9)
- (4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)(2-(p-tolylthio)pyridin-3-yl)methanone (CAS 1022407-10-8)
- 2-(4-Chlorobenzoyl)-3-({[3-(trifluoromethyl)phenyl]methanesulfonyl}methyl)-1-benzofuran (CAS 338424-36-5)
- Empagliflozin Impurity 219 (CAS CATO-C4X-1065219)
- Sildenafil Impurity 301 (CAS CATO-C4X-1128301)
- Ivabradine Impurity 17 (CAS 304462-60-0)
- Ramosetron Impurity 15 (CAS 26751-24-6)
- 3,14-Dihydroxymorphinan (CAS 3792-68-5)
- 1-Ethyl-6,7-dimethoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (CAS 32932-16-4)
- 8-Chloro-3-(difluoromethyl)-6-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine (CAS 478248-92-9)
- 4-Amino-6-cyano-3-(difluoromethyl)picolinoyl chloride (CAS 1805111-22-1)
- 2-Iodopyridin-3-yl benzoate (CAS 245039-51-4)
- 2-Amino-1-((S)-3-(benzyl(cyclopropyl)amino)pyrrolidin-1-yl)propan-1-one (CAS 1354024-64-8)
- Insulin Degludec Impurity 5 (CAS CATO-C4X-21575)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com