5-[2-(Trifluoromethyl)phenyl]-1H-indole-2,3-dione CAS 893737-48-9
| CAS No. | 893737-48-9 |
| Molecular Formula | C15H8F3NO2 |
| Molecular Weight | 291.22 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 5-[2-(Trifluoromethyl)phenyl]-1H-indole-2,3-dione.
5-[2-(Trifluoromethyl)phenyl]-1H-indole-2,3-dione (CAS 893737-48-9), molecular formula C15H8F3NO2 and molecular weight 291.22 g/mol, is a CATO reference standard with documented purity and traceability.
Based on its molecular formula C15H8F3NO2, 5-[2-(Trifluoromethyl)phenyl]-1H-indole-2,3-dione contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 291.22 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H8F3NO2 |
| Molecular Weight | 291.22 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Trifluoromethyl Standards
- 5-[3-(Trifluoromethyl)phenyl]-1H-indole-2,3-dione (CAS 893736-61-3)
- 5-[4-(Trifluoromethyl)phenyl]-1H-indole-2,3-dione (CAS 893736-59-9)
- 1-(6-Oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-2-yl)piperidine-4-carboxylic acid (CAS 1248546-34-0)
- 1-(6-Oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-2-yl)piperidine-3-carboxylic acid (CAS 1248561-09-2)
- 2-{5-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl}pyridine (CAS 327056-10-0)
- 4-{5-[2-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl}pyridine (CAS 339104-49-3)
- 7-[3-(Trifluoromethyl)pyridin-2-yl]quinazolin-4-ol (CAS 573675-81-7)
- 2-{[2-methyl-4-(trifluoromethyl)-2h-pyrazolo[3,4-b]pyridin-6-yl]sulfanyl}acetic acid (CAS 1018046-75-7)
Recommended Standards
- 3'-Formyl-4'-(trifluoromethoxy)-[1,1'-biphenyl]-4-carbonitrile (CAS 923281-51-0)
- 3-Bromo-2-(oct-1-en-3-yloxy)tetrahydro-2H-pyran (CAS 349543-87-9)
- 3,5-Dimethyl-1-((perfluorophenyl)methyl)-1h-pyrazol-4-amine (CAS 895929-03-0)
- 5-Oxo-5-((4-(trifluoromethoxy)phenyl)amino)pentanoic acid (CAS 298215-31-3)
- 2-Fluoro-2',4'-dimethyl-[1,1'-biphenyl]-4-amine (CAS 1486200-14-9)
- 2,3,5,6-Tetramethylpyrazine hydrochloride (CAS 126400-81-5)
- Quinoline-5-carbohydrazide (CAS 96541-83-2)
- Bis(1,3-dithian-2-yl)methane-d2 (CAS 105479-87-6)
- 3-Iodo-1-methyl-6-(trifluoromethoxy)-1H-indazole (CAS 1823529-94-7)
- 1-Ethyl-3-methyl-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-pyrazole (CAS 2019997-43-2)
- Sarmentosin (CAS 71933-54-5)
- 2-Chloro-3-(piperidin-1-ylmethyl)pyridine (CAS 1250675-90-1)
- N-(2,4-Dichlorophenyl)-2-(4-methoxybenzenesulfinyl)acetamide (CAS 339107-98-1)
- Semaglutide Impurity 10 (CAS CATO-C4X-222610)
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