Dextromethorphan Impurity 33 CAS 89511-04-6
| CAS No. | 89511-04-6 |
| Molecular Formula | C17H21NO |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Dextromethorphan Impurity 33.
As a process- or degradation-related impurity, Dextromethorphan Impurity 33 (CAS 89511-04-6, C17H21NOHCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C17H21NOHCl, Dextromethorphan Impurity 33 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 291.82 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H21NO HCl |
| Molecular Weight | 291.82 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1982 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Dextromethorphan Standards
- Dextromethorphan impurity 41 (CAS 1058187-40-8)
- Dextromethorphan EP Impurity A Hydrochloride (CAS 1087-69-0)
- Dextromethorphan N-Oxide（HCl） (CAS 1177419-85-0)
- Dextromethorphan N-Oxide (CAS 1177494-18-6)
- Dextromethorphan Impurity 3-methoxy-17-methyl-morphinan-10β-ol Formic acid (CAS 120442-81-1（free base）)
- Dextromethorphan (CAS 125-69-9)
- Dextromethorphan impurity 23 (CAS 125-70-2)
- Dextromethorphan EP Impurity B (CAS 125-73-5)
Recommended Standards
- Benzylpenicillin EP Impurity D (CAS 13093-87-3)
- Capivasertib Impurity 6 (CAS 27646-81-7)
- Trametinib Impurity 1 (CAS 871700-28-6)
- ((2R,3S,4R,5S)-3,4,5-Trihydroxytetrahydro-2H-pyran-2-yl)methyl dihydrogen phosphate (CAS 17659-59-5)
- 898768-13-3 1-(3,5-Dichlorophenyl)-3-(3-methylphenyl)propan-1-one DTXSID30644097 (CAS 898768-13-3)
- N-(6-tert-Butyl-3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-2-chloropropanamide (CAS 1365963-84-3)
- 5-(3,4-Diethoxyphenyl)-3-phenyl-1H-1,2,4-triazole (CAS 1416342-22-7)
- 2-Amino-5-bromo-3-(trifluoromethyl)benzoic acid, 97% (CAS 50419-85-7)
- Magnesium aluminum i-propoxide (99.99%-Mg) PURATREM (CAS 69207-83-6)
- Semaglutide impurity 88 (CAS CATO-C4X-222688)
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