Trametinib Impurity 1 CAS 871700-28-6
| CAS No. | 871700-28-6 |
| Molecular Formula | C13H11FIN3O2 |
| Molecular Weight | 387.15 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Trametinib Impurity 1 (CAS 871700-28-6, C13H11FIN3O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Trametinib Impurity 1 (C13H11FIN3O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/iodine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
CATO manufactures Trametinib Impurity 1 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C13H11FIN3O2 |
| Molecular Weight | 387.15 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/I-containing |
| Nitrogen Atoms | 3 |
Related Trametinib Standards
- Trametinib impurity 8 (CAS 871700-26-4)
- Trametinib Impurity N9 (CAS 871700-41-3)
- Trametinib impurity 7 (CAS 871700-22-0)
- Trametinib impurity 11 (CAS CATO-C4X-278211)
- Trametinib impurity 12 (CAS 3018911-27-5)
- Trametinib Impurity N1 (CAS 329941-39-1)
- Trametinib impurity 03 (CAS 871700-24-2)
- Trametinib Impurity 16 (CAS CATO-C4X-278216)
Recommended Standards
- 6-(4-Bromophenyl)-7-methyl-2-(trifluoromethyl)-7H-pyrimido[4,5-b][1,4]oxazin-4-amine (CAS 1956382-27-6)
- Isopropyl (2-iodo-4-methyl-5-(trifluoromethyl)phenyl)carbamate (CAS 872624-69-6)
- Dibutyldiphenyltin (CAS 6452-61-5)
- 3-(2,4-Dichloro-5-fluorophenyl)-1-(2,4-difluorophenyl)-1H-pyrazole-5-carboxylic acid (CAS 618382-97-1)
- Vortioxetine Impurity 15 (CAS 3070439-20-9)
- Nefopam Impurity 3 (CAS CATO-C4X-28383)
- Orforglipron impurity 79 (CAS CATO-C4X-323479)
- Penconazole (CAS 66246-88-6)
- ACY-1215, 98% (CAS 1316214-52-4)
- 4-Chloro-3-fluoro-2-hydroxybenzoic acid (CAS 1702676-05-8)
- Tert-butyl (R)-2-isopropyl-4-oxopiperidine-1-carboxylate (CAS 1217662-38-8)
- trans Resveratrol-4'-sulfate (CAS 858187-19-6)
- 2-(4-(2-Bromoethyl)phenyl)-2-methylpropanoic acid (CAS 948552-52-1)
- Peptide 434 (CAS CATO-CPTD788434)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com