4-Chloro-7-(trifluoromethyl)quinoline-3-carboxylic acid CAS 89524-63-0
| CAS No. | 89524-63-0 |
| Molecular Formula | C11H5ClF3NO2 |
| Molecular Weight | 275.61 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4-Chloro-7-(trifluoromethyl)quinoline-3-carboxylic acid (CAS 89524-63-0) is a high-purity analytical reference standard with the molecular formula C11H5ClF3NO2 and a molecular weight of 275.61 g/mol.
The molecular framework of 4-Chloro-7-(trifluoromethyl)quinoline-3-carboxylic acid (C11H5ClF3NO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H5ClF3NO2 |
| Molecular Weight | 275.61 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1982 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- 7-Chloro-3-(trifluoromethyl)quinoline-8-carboxylic acid (CAS 114012-29-2)
- 5-Chloro-3-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carbaldehyde (CAS 1188136-23-3)
- 5-Chloro-3-[3-(trifluoromethyl)phenyl]-1,2-oxazole-4-carbaldehyde (CAS 1188136-36-8)
- 2-Chloro-7-(trifluoromethoxy)quinoline-3-carbaldehyde (CAS 1254366-15-8)
- 2-Chloro-6-(trifluoromethoxy)quinoline-3-carbaldehyde (CAS 1956376-56-9)
- 1-(4-Chloro-3-(trifluoromethyl)phenyl)-1h-pyrrole-2,5-dione (CAS 54647-10-8)
- 1-[2-chloro-5-(trifluoromethyl)phenyl]-2,5-dihydro-1H-pyrrole-2,5-dione (CAS 34520-60-0)
- 2-Chloro-3-(trifluoromethyl)quinoline-8-carboxylic acid (CAS 590372-14-8)
Recommended Standards
- 3-Hydroxy-8-(trifluoromethyl)quinoline-4-carbonyl chloride (CAS 924635-09-6)
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- 4-Hydroxy-7-(trifluoromethyl)quinoline-3-carbonyl chloride (CAS 59197-90-9)
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