Rivaroxaban Impurity 33 CAS 898543-06-1
| CAS No. | 898543-06-1 |
| Molecular Formula | C14H17N3O4 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Rivaroxaban Impurity 33 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 327.76 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Rivaroxaban Impurity 33 (CAS 898543-06-1, C14H17N3O4HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H17N3O4 HCl |
| Molecular Weight | 327.76 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Rivaroxaban Standards
- Rivaroxaban Impurity 96 (CAS 1007650-38-5)
- Rivaroxaban Impurity 57 (CAS 1082495-22-4)
- Rivaroxaban Impurity 47 (CAS 1082588-73-5)
- Rivaroxaban-d4 (CAS 1132681-38-9)
- Rivaroxaban Impurity 74 (CAS 113471-08-2)
- Rivaroxaban EP Impurity I (CAS 1151893-81-0)
- Rivaroxaban 3-Hydroxy Metabolite (CAS 1159977-46-4)
- Rivaroxaban Impurity 15 (Mixture of Diastereomers) (CAS 1160169-99-2)
Recommended Standards
- Rapamycin Impurity 31 (CAS CATO-C4X-174631)
- Lenvatinib Impurity 27 (CAS 2868-37-3)
- Brimonidine EP Impurity E (CAS 168329-48-4)
- (S)-1-Amino-6-fluoro-2,3-dihydroindene Hydrochloride (CAS 1391354-92-9)
- Desogestrel (CAS 54024-22-5)
- N-{2-[5-(2-hydroxyethoxy)-1H-indol-3-yl]ethyl}acetamide (CAS 214416-49-6)
- (4-(4-Chlorophenyl)-5-(2'-fluoro-4'-propyl-[1,1'-biphenyl]-4-yl)-1H-pyrazol-1-yl)(p-tolyl)methanone (CAS 477762-86-0)
- (1R,2R)-1-iodo-2-(perfluoropropyl)cyclohexane (CAS 7589-43-7)
- DL-Alanine-3,3,3-d3 (CAS 53795-94-1)
- Semaglutide impurity 56 (CAS CATO-C4X-222656)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com