(2-((1,4-Dioxa-8-azaspiro[4.5]Decan-8-yl)methyl)phenyl)(2,5-dichlorophenyl)methanone CAS 898756-54-2
| CAS No. | 898756-54-2 |
| Molecular Formula | C21H21Cl2NO3 |
| Molecular Weight | 406.30 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies (2-((1,4-Dioxa-8-azaspiro[4.5]Decan-8-yl)methyl)phenyl)(2,5-dichlorophenyl)methanone (CAS 898756-54-2), a certified reference material (molecular formula C21H21Cl2NO3, MW 406.30 g/mol) for analytical method development and quality control.
The molecular framework of (2-((1,4-Dioxa-8-azaspiro[4.5]Decan-8-yl)methyl)phenyl)(2,5-dichlorophenyl)methanone (C21H21Cl2NO3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C21H21Cl2NO3 |
| Molecular Weight | 406.30 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Dioxa Standards
- (2-((1,4-Dioxa-8-azaspiro[4.5]Decan-8-yl)methyl)phenyl)(2,3-dichlorophenyl)methanone (CAS 898756-48-4)
- (2-((1,4-Dioxa-8-azaspiro[4.5]Decan-8-yl)methyl)phenyl)(2,4-dichlorophenyl)methanone (CAS 898756-51-9)
- (2-((1,4-Dioxa-8-azaspiro[4.5]Decan-8-yl)methyl)phenyl)(3,4-dichlorophenyl)methanone (CAS 898756-57-5)
- (2-((1,4-Dioxa-8-azaspiro[4.5]Decan-8-yl)methyl)phenyl)(3,5-dichlorophenyl)methanone (CAS 898756-60-0)
- (3-((1,4-Dioxa-8-azaspiro[4.5]Decan-8-yl)methyl)phenyl)(2,3-dichlorophenyl)methanone (CAS 898762-19-1)
- (3-((1,4-Dioxa-8-azaspiro[4.5]Decan-8-yl)methyl)phenyl)(2,4-dichlorophenyl)methanone (CAS 898762-22-6)
- (3-((1,4-Dioxa-8-azaspiro[4.5]Decan-8-yl)methyl)phenyl)(2,5-dichlorophenyl)methanone (CAS 898762-25-9)
- (3-((1,4-Dioxa-8-azaspiro[4.5]Decan-8-yl)methyl)phenyl)(3,4-dichlorophenyl)methanone (CAS 898762-28-2)
Recommended Standards
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- tert-Butyl 4-(3-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperazine-1-carboxylate (CAS 1129541-83-8)
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- N-(3-Fluorobenzyl)-4-iodoaniline (CAS 1040064-37-6)
- Semaglutide impurity 233 (CAS CATO-C4X-2226233)
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