(3-Chloro-5-fluorophenyl)(cyclopentyl)methanone CAS 898791-72-5
| CAS No. | 898791-72-5 |
| Molecular Formula | C12H12ClFO |
| Molecular Weight | 226.67 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
(3-Chloro-5-fluorophenyl)(cyclopentyl)methanone (CAS 898791-72-5), molecular formula C12H12ClFO and molecular weight 226.67 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of (3-Chloro-5-fluorophenyl)(cyclopentyl)methanone (C12H12ClFO) is characterized by a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H12ClFO |
| Molecular Weight | 226.67 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- 5-(2-(4-Chloro-3,5-dimethyl-1h-pyrazol-1-yl)ethyl)-2h-tetrazole (CAS 1005566-25-5)
- (5-Chloro-2-fluorophenyl)(cyclopentyl)methanone (CAS 1368672-87-0)
- (2-Chloro-6-fluorophenyl)(cyclopentyl)methanone (CAS 1443342-98-0)
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- 1-(3-Chloro-4-fluorophenyl)-3-cyclopropylpropan-1-one (CAS 1477686-15-9)
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- (2-Chloro-4-fluorophenyl)(cyclopentyl)methanone (CAS 898791-70-3)
- (3-Chloro-4-fluorophenyl)(cyclopentyl)methanone (CAS 898791-62-3)
Recommended Standards
- (4-Chloro-2-fluorophenyl)(cyclopentyl)methanone (CAS 898791-75-8)
- (4-Chloro-3-fluorophenyl)(cyclopentyl)methanone (CAS 898791-60-1)
- 2-[Chloro(4-Fluorophenyl)Methylene]Valeraldehyde (CAS 83706-47-2)
- 3-Butyl-7-chloro-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-amine (CAS 92307-09-0)
- Magnesium chloride dihydrate (CAS 19098-17-0)
- 4,6-Dibromo-2-(3,4-dimethylphenyl)-1,3-benzoxazol-5-amine (CAS 637302-96-6)
- 1-{5-[(4-chlorophenyl)sulfanyl]-4-phenyl-1,3-thiazol-2-yl}-4-(2-methylpropane-2-sulfonyl)-1H-pyrazol-5-amine (CAS 956606-61-4)
- 4-Chloro-2-(trifluoromethyl)-4-chloro-2-(trifluoromethyl)-1,1'-biphenyl (CAS 1214387-07-1)
- Dopamine Impurity 33 (CAS CATO-C4X-190833)
- 6-Bromo-N-(piperidin-4-yl)pyridin-2-amine hydrochloride (CAS 1185315-52-9)
- N-[(4-Methoxyphenyl)methyl]-4H-3,1-benzothiazin-2-amine (CAS 320419-97-4)
- 2'-Methoxy-4'-methyl-[1,1'-biphenyl]-3-carboxylic acid (CAS 1215205-41-6)
- 2,7-Dimethyldibenzo[b,d]furan (CAS 51801-70-8)
- Semaglutide impurity 236 (CAS CATO-C4X-2226236)
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