2-(3-Chloro-4-fluorophenyl)piperidine CAS 901921-07-1
| CAS No. | 901921-07-1 |
| Molecular Formula | C11H13ClFN |
| Molecular Weight | 213.68 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 2-(3-Chloro-4-fluorophenyl)piperidine is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
2-(3-Chloro-4-fluorophenyl)piperidine (CAS 901921-07-1) is a high-purity analytical reference standard with the molecular formula C11H13ClFN and a molecular weight of 213.68 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution, 2-(3-Chloro-4-fluorophenyl)piperidine is typically off-white to pale yellow low-melting solid. Its solid-state physicochemical attributes — including a molecular weight of 213.68 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-(3-Chloro-4-fluorophenyl)piperidine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H13ClFN |
| Molecular Weight | 213.68 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- 4-(5-Chloro-2-fluorophenyl)piperidine (CAS 1004852-70-3)
- n-(2-Chloro-6-fluorobenzyl)-1-cyclopropylmethanamine (CAS 1019504-28-9)
- [(2-chloro-4-fluorophenyl)methyl](cyclopropylmethyl)amine (CAS 1020979-51-4)
- 1-(3-Chloro-4-fluorophenyl)piperidine (CAS 1033201-89-6)
- 3-Chloro-N-cyclopentyl-4-fluoroaniline (CAS 1039901-64-8)
- (1-(2-Chloro-6-fluorophenyl)cyclobutyl)methanamine (CAS 1039932-28-9)
- 3-(4-Chloro-3-fluorophenyl)piperidine (CAS 1044765-40-3)
- 3-(3-Chloro-4-fluorophenyl)piperidine (CAS 1044768-68-4)
Recommended Standards
- 2-(2-Chloro-6-fluorophenyl)-4-methylpyrrolidine (CAS 603089-82-3)
- 2,6-Dimethylmorpholine-4-sulfonyl chloride (CAS 919026-20-3)
- 1-(2-Chloro-4-fluorobenzyl)pyrrolidine (CAS 891395-75-8)
- 2-Chloro-4-ethoxy-1,3-benzothiazole (CAS 890091-95-9)
- 2-[(ethylsulfonyl)amino]-4-(methylthio)butanoic acid (CAS 1009529-97-8)
- 3-Chloro-4-methylphenethyl ethyl oxalate (CAS 1443353-83-0)
- (4-Aminophenyl)(1-benzofuran-2-yl)methanone (CAS 92789-48-5)
- Clindamycin Phosphate EP Impurity E (CAS 18323-44-9)
- 2-Chloro-N-(1-phenylbutyl)propanamide (CAS 40023-54-9)
- Sugammadex Sodium Impurity 85 (CAS CATO-C4X-190685)
- β-Estradiol 3-benzoate 17-n-butyrate (CAS 63042-18-2)
- Methylammonium Acetate (CAS 6998-30-7)
- Methyl 2-methyl-6-oxo-4-(4-(trifluoromethyl)phenyl)-1,4,5,6-tetrahydropyridine-3-carboxylate (CAS 330216-62-1)
- Tirzepatide Impurity 37 (CAS CATO-C4X-324037)
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