Phenoxybenzamine EP Impurity A CAS 902273-13-6
| CAS No. | 902273-13-6 |
| Molecular Formula | C18H22ClNO |
| Molecular Weight | 303.83 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Phenoxybenzamine EP Impurity A (CAS 902273-13-6, C18H22ClNO) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Phenoxybenzamine EP Impurity A (C18H22ClNO) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Phenoxybenzamine EP Impurity A meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H22ClNO |
| Molecular Weight | 303.83 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Phenoxybenzamine Standards
- Phenoxybenzamine - API Standards (CAS 59-96-1)
- Phenoxybenzamine-d5 (CAS 1188265-52-2)
- Phenoxybenzamine Impurity 3 (CAS 2512203-93-7)
- Phenoxybenzamine EP Impurity B (CAS 101-45-1)
- Phenoxybenzamine Impurity 4 (CAS 76805-26-0)
- Phenoxybenzamine EP Impurity C (CAS 854881-53-1)
- Phenoxybenzamine Impurity A (CAS 68157-86-8)
- Phenoxybenzamine-D5 Hydrochloride (CAS 1329838-45-0)
Recommended Standards
- Chlorphenoxamine (CAS 77-38-3)
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