Ezetimibe Impurity 52 CAS 90319-52-1
| CAS No. | 90319-52-1 |
| Molecular Formula | C9H9NO2 |
| Molecular Weight | 163.17 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Ezetimibe Impurity 52 (CAS 90319-52-1, C9H9NO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Ezetimibe Impurity 52 (C9H9NO2) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. The carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Ezetimibe Impurity 52 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H9NO2 |
| Molecular Weight | 163.17 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1982 |
| Nitrogen Atoms | 1 |
Related Ezetimibe Standards
- Ezetimibe Impurity 34 (CAS 99395-88-7)
- Ezetimibe Impurity 60 (CAS 538-51-2)
- Ezetimibe Impurity 119 (CAS 914777-32-5)
- Ezetimibe Impurity 112 (CAS CATO-C4X-1098112)
- Ezetimibe Impurity 113 (CAS CATO-C4X-1098113)
- Ezetimibe Impurity 118 (CAS CATO-C4X-1098118)
- Ezetimibe Impurity 111 (CAS CATO-C4X-1098111)
- Ezetimibe Impurity 51 (CAS 693-13-0)
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