Amlodipine Impurity 24 CAS 90445-14-0
| CAS No. | 90445-14-0 |
| Molecular Formula | C20H22ClNO7 |
| Molecular Weight | 423.84 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Amlodipine Impurity 24 (CAS 90445-14-0) is a certified pharmaceutical impurity reference standard with the molecular formula C20H22ClNO7 and a molecular weight of 423.84 g/mol.
The molecular framework of Amlodipine Impurity 24 (C20H22ClNO7) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Amlodipine Impurity 24 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H22ClNO7 |
| Molecular Weight | 423.84 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1982 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Amlodipine Standards
- Amlodipine Impurity 80 (CAS CATO-C4X-109580)
- Amlodipine Impurity 99 (CAS CATO-C4X-109599)
- Amlodipine Impurity 153 (CAS 2923811-73-6)
- Amlodipine Besylate EP Impurity E (CAS 140171-65-9)
- Amlodipine impurity 68 (CAS 88150-30-5)
- Amlodipine impurity 9 (CAS CATO-C4X-10959)
- Amlodipine Impurity 56 (CAS 2418591-36-1)
- Amlodipine Metabolite 4 (CAS 113994-45-9)
Recommended Standards
- 3-(2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]sulfanyl}phenyl)-1-phenylurea (CAS 338773-30-1)
- (4S)-3-[(2R,3R)-4-Chloro-3-(2,4-difluorophenyl)-3-hydroxy-2-methyl-1-oxobutyl]-4-(phenylmethyl)-2-oxazolidinone (CAS 169218-76-2)
- Isa-2011b (CAS 1395347-24-6)
- Methyl (2Z)-2-{1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-1H-indol-3-yl}-3-(dimethylamino)prop-2-enoate (CAS 339099-30-8)
- Duloxetine Impurity 33 (CAS CATO-C4X-133633)
- Ensifentrine impurity 38 (CAS CATO-C4X-335338)
- Tofacitinib Impurity 22 (CAS 2227199-28-0)
- Bis((1,4,7,10,13-pentaoxacyclopentadecan-2-yl)methyl) 2-dodecyl-2-methylmalonate (CAS 87505-87-1)
- 3-{[(4-fluorophenyl)methyl]sulfanyl}-5-methyl-1,2-thiazole-4-carbonitrile (CAS 339021-11-3)
- 4-(2-(2-Ethoxyethoxy)ethoxy)aniline (CAS 90688-48-5)
- Vigabatrin HCl (CAS 1391054-02-6)
- Eldecalcitol Impurity 40 (CAS 1217549-29-5)
- Salbutamol Impurity 77 (CAS 39235-57-9)
- Semaglutide impurity 200 (CAS CATO-C4X-2226200)
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