Semaglutide impurity 77 CAS CATO-C4X-222677
| CAS No. | CATO-C4X-222677 |
| Molecular Formula | C12H18N4O4 |
| Molecular Weight | 282.30 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Semaglutide impurity 77 (CAS CATO-C4X-222677) is a certified pharmaceutical impurity reference standard with the molecular formula C12H18N4O4 and a molecular weight of 282.30 g/mol.
Structurally, Semaglutide impurity 77 (C12H18N4O4) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 282.30 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), Semaglutide impurity 77 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H18N4O4 |
| Molecular Weight | 282.30 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 4 |
Related Semaglutide Standards
- Semaglutide Impurity 140 (CAS CATO-C4X-2226140)
- Semaglutide impurity 92 (CAS CATO-C4X-222692)
- Semaglutide Impurity 138 (CAS CATO-C4X-2226138)
- Semaglutide Impurity 5 (CAS 23406-82-8)
- semaglutide (CAS 782487-28-9)
- Semaglutide impurity 331 (CAS CATO-C4X-2226231)
- Semaglutide impurity 206 (CAS CATO-C4X-2226206)
- Semaglutide impurity 58 (CAS CATO-C4X-222658)
Recommended Standards
- Nevirapine N1-Oxide (CAS 162255-73-4)
- carbamic acid, [2-[(4-fluoro-2-methylphenyl)amino]-2-oxoethyl]-, 1,1-dimethylethyl ester (CAS 1043391-02-1)
- Pixantrone Impurity 2 (CAS 1430561-04-8)
- N4-(3-Fluorophenyl)-N2-isobutyl-L-asparagine (CAS 1048006-02-5)
- Daptomycin Impurity 35 (CAS CATO-C4X-137835)
- Tolvaptan Impurity 101 (CAS CATO-C4X-1955101)
- Tegoprazan Impurity 136 (CAS CATO-C4X-2297136)
- Desmopressin EP Impurity D (CAS CATO-C4X-221526)
- 2-((3-Cyano-4-phenyl-6-(p-tolyl)pyridin-2-yl)thio)-N-(4-methoxy-2-nitrophenyl)acetamide (CAS 332154-85-5)
- (2-chloro-5-hydroxybenzoyl)glycine (CAS 1694432-26-2)
- (8-Hydroxy-3,4-dihydroquinolin-1(2H)-yl)(pyridin-3-yl)methanone (CAS 77771-22-3)
- 1-Methoxy-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile (CAS 446276-10-4)
- 6-(Difluoromethyl)pyrimidine-4,5-diamine (CAS 1706442-59-2)
- Bradykinin-Like Neuropeptide (Aplysia californica) (H-1654.0001) (CAS 165174-60-7)
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