Nebivolol Impurity 21 CAS 914207-85-5
| CAS No. | 914207-85-5 |
| Molecular Formula | C10H9FO4 |
| Molecular Weight | 212.17 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 212.17 g/mol gives Nebivolol Impurity 21 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Nebivolol Impurity 21 (CAS 914207-85-5), a pharmacopoeial impurity reference standard (molecular formula C10H9FO4, MW 212.17 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Nebivolol Impurity 21 (C10H9FO4) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 212.17 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Nebivolol Impurity 21 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H9FO4 |
| Molecular Weight | 212.17 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
Related Nebivolol Standards
- Nebivolol Impurity 52 (CAS 303176-45-6)
- Nebivolol Impurity 53 (CAS 303176-43-4)
- Nebivolol Impurity 54 (CAS 303176-39-8)
- Nebivolol Impurity 22 (CAS 1529280-40-7)
- Nebivolol Impurity 62 (CAS CATO-C4X-196862)
- Nebivolol Impurity 63 (CAS CATO-C4X-196863)
- Nebivolol Impurity 20 (CAS 105300-40-1)
- Nebivolol Impurity 1 (CAS 1346562-34-2)
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- Probenecid Impurity 9 (CAS 141284-78-8)
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