Nebivolol Impurity 63 CAS CATO-C4X-196863
| CAS No. | CATO-C4X-196863 |
| Molecular Formula | C11H11FO3 |
| Molecular Weight | 210.20 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Nebivolol Impurity 63.
As a process- or degradation-related impurity, Nebivolol Impurity 63 (CAS CATO-C4X-196863, C11H11FO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system, Nebivolol Impurity 63 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 210.20 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Nebivolol Impurity 63 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H11FO3 |
| Molecular Weight | 210.20 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
Related Nebivolol Standards
- Nebivolol Impurity 22 (CAS 1529280-40-7)
- Nebivolol Impurity 62 (CAS CATO-C4X-196862)
- Nebivolol Impurity 20 (CAS 105300-40-1)
- Nebivolol Impurity 21 (CAS 914207-85-5)
- Nebivolol Impurity 52 (CAS 303176-45-6)
- Nebivolol Impurity 53 (CAS 303176-43-4)
- Nebivolol Impurity 54 (CAS 303176-39-8)
- Nebivolol Impurity 1 (CAS 1346562-34-2)
Recommended Standards
- Regadenoson Impurity 27 (CAS 89365-25-3)
- Lemborexant Impurity 65 (CAS 3070371-35-3)
- 5-(2-fluorophenyl)-5-oxopentanoic acid (CAS 199664-70-5)
- Lemborexant Impurity 66 (CAS 1450905-00-6)
- Domperidone Impurity 30 (CAS CATO-C4X-142030)
- LCZ-696 Impurity 76 (CAS CATO-C4X-169676)
- Alogliptin Impurity 26 (CAS CATO-C4X-109926)
- Methyl 6-cyclopropyl-1-ethyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylate (CAS 1018125-75-1)
- Ensifentrine impurity 35 (CAS CATO-C4X-335335)
- 1-(tert-Butoxycarbonyl)-4-(2-oxopropyl)piperidine-4-carboxylic acid (CAS 1897839-44-9)
- Perfluorocarboxylic acid (CAS 35576-88-6)
- (E)-[1-(1,3-Thiazol-2-yl)ethylidene]amino 3-(2-chloro-6-fluorophenyl)-5-methyl-1,2-oxazole-4-carboxylate (CAS 866149-47-5)
- 4-(Indolin-1-yl)benzoic acid (CAS 1020933-45-2)
- (10-31)Semaglutide (CAS CATO-C4X-2226283)
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