Nebivolol Impurity 20 CAS 105300-40-1

Description

Compared with other compounds in its class, the molecular weight of 210.16 g/mol gives Nebivolol Impurity 20 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.

Nebivolol Impurity 20 (CAS 105300-40-1) is a certified pharmaceutical impurity reference standard with the molecular formula C10H7FO4 and a molecular weight of 210.16 g/mol.

Nebivolol Impurity 20 (C10H7FO4) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).

Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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