Bromfenac Impurity 19 CAS 91713-91-6
| CAS No. | 91713-91-6 |
| Molecular Formula | C15H10BrNO2 |
| Molecular Weight | 316.15 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Bromfenac Impurity 19 (CAS 91713-91-6) is a certified pharmaceutical impurity reference standard with the molecular formula C15H10BrNO2 and a molecular weight of 316.15 g/mol.
Bromfenac Impurity 19 (C15H10BrNO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C15H10BrNO2 |
| Molecular Weight | 316.15 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1983 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Bromfenac Standards
- Bromfenac Impurity 20 (CAS CATO-C4X-200220)
- Bromfenac Impurity 21 (CAS CATO-C4X-200221)
- Bromfenac Impurity 28 (CAS 91714-41-9)
- Bromfenac lmpurity 58 (CAS CATO-C4X-200258)
- Bromfenac Impurity 67 (CAS CATO-C4X-200267)
- Bromfenac Impurity 68 (CAS CATO-C4X-200268)
- Bromfenac Impurity 78 (CAS CATO-C4X-200278)
- Bromfenac Impurity 24 (CAS 241825-88-7)
Recommended Standards
- Netupitant Impurity 31 (CAS 1444338-30-0)
- Mosapride Impurity 24 (CAS 483304-07-0)
- tert-Butyl 5-(bromomethyl)-2-nitrobenzoate (CAS 88071-92-5)
- Crisaborole impurity 132 (CAS CATO-C4X-2021132)
- Esomeprazole Impurity 80 (CAS CATO-C4X-111280)
- Loratadine Impurity 93 (CAS CATO-C4X-142693)
- Tunodafil Impurity 4 HCl (CAS CATO-C4X-31104)
- 1-(4-Chlorophenyl)-3-(ethoxycarbonyl)-5-methyl-4,5-dihydro-1h-pyrazole-5-carboxylic acid (CAS 1264048-83-0)
- Ethyl 3-pyridin-3-yl-[1,2,4]oxadiazole-5-carboxylate (CAS 163719-72-0)
- 4,6-Dimethylpyrimidine-2-carboximidamide (CAS 45938-61-2)
- Ethyl (2-cyano-4-nitrophenyl)glycinate (CAS 1158272-89-9)
- N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1H-pyrazole-3-carboxamide (CAS 379255-85-3)
- 1-(3-Methoxyphenyl)-N-methylbutan-1-amine (CAS 941002-18-2)
- Liraglutide Impurity 28 (CAS CATO-C4X-199228)
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