Bromfenac Impurity 21 CAS CATO-C4X-200221
| CAS No. | CATO-C4X-200221 |
| Molecular Formula | C15H10BrNO2 |
| Molecular Weight | 316.15 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Bromfenac Impurity 21 is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Bromfenac Impurity 21 (CAS CATO-C4X-200221, C15H10BrNO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Bromfenac Impurity 21 (C15H10BrNO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Bromfenac Impurity 21 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H10BrNO2 |
| Molecular Weight | 316.15 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Bromfenac Standards
- Bromfenac Impurity 19 (CAS 91713-91-6)
- Bromfenac Impurity 20 (CAS CATO-C4X-200220)
- Bromfenac Impurity 28 (CAS 91714-41-9)
- Bromfenac lmpurity 58 (CAS CATO-C4X-200258)
- Bromfenac Impurity 67 (CAS CATO-C4X-200267)
- Bromfenac Impurity 68 (CAS CATO-C4X-200268)
- Bromfenac Impurity 78 (CAS CATO-C4X-200278)
- Bromfenac Impurity 24 (CAS 241825-88-7)
Recommended Standards
- Crisaborole impurity 132 (CAS CATO-C4X-2021132)
- Bromazepam EP Impurity D (CAS 77616-97-8)
- Netupitant Impurity 31 (CAS 1444338-30-0)
- (4-((3,5-Dimethoxybenzyl)oxy)-3,5-dimethylphenyl)boronic acid (CAS 1072951-94-0)
- Aripiprazole Impurity 60 (CAS CATO-C4X-100860)
- Cloxacillin Impurity 42 (CAS CATO-C4X-232142)
- Opicapone impurity 71 (CAS CATO-C4X-240471)
- methyl 4-chloro-1H-pyrrolo[2,3-b]pyridine-3-carboxylate (CAS 1234616-82-0)
- Methyl 2-Butyloxazole-4-carboxylate (CAS 140381-01-7)
- 3-(Bromomethyl)-3-methylazetidine (CAS 2167769-21-1)
- Sulfuric acid, monoethenyl ester, homopolymer (CAS 25191-25-7)
- 4-Chlorobenzo[d]thiazol-7-amine (CAS 70202-02-7)
- N-(Ethoxycarbonyl)nortropinone (CAS 32499-64-2)
- Fragment-[3-31]-Liraglutide (CAS CATO-C4X-199232)
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