Bromfenac Impurity 53 CAS 91714-50-0
| CAS No. | 91714-50-0 |
| Molecular Formula | C15H10BrNO |
| Molecular Weight | 300.15 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Bromfenac Impurity 53.
As a process- or degradation-related impurity, Bromfenac Impurity 53 (CAS 91714-50-0, C15H10BrNO) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Bromfenac Impurity 53 (C15H10BrNO) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Bromfenac Impurity 53 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H10BrNO |
| Molecular Weight | 300.15 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1983 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Bromfenac Standards
- Bromfenac Impurity 52 (CAS CATO-C4X-200252)
- Bromfenac Impurity 62 (CAS CATO-C4X-200262)
- Bromfenac Impurity 71 (CAS CATO-C4X-200271)
- Bromfenac Impurity 28 (CAS 91714-41-9)
- Bromfenac lmpurity 58 (CAS CATO-C4X-200258)
- Bromfenac Impurity 67 (CAS CATO-C4X-200267)
- Bromfenac Impurity 68 (CAS CATO-C4X-200268)
- Bromfenac Impurity 78 (CAS CATO-C4X-200278)
Recommended Standards
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- Ethyl 2-[(2-nitrophenyl)amino]acetate (CAS 5428-05-7)
- 2-Bromo-N-(3-nitro-phenyl)-butyramide (CAS 300707-59-9)
- Insulin Degludec Impurity 27 (CAS CATO-C4X-215727)
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