Carbamazepine Impurity 32 CAS 40421-05-4
| CAS No. | 40421-05-4 |
| Molecular Formula | C15H10BrNO |
| Molecular Weight | 300.15 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Carbamazepine Impurity 32 (CAS 40421-05-4) is a certified pharmaceutical impurity reference standard with the molecular formula C15H10BrNO and a molecular weight of 300.15 g/mol.
The molecular framework of Carbamazepine Impurity 32 (C15H10BrNO) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C15H10BrNO |
| Molecular Weight | 300.15 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1968 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Carbamazepine Standards
- Carbamazepine 10-Acetoxy Impurity (CAS 952740-00-0)
- Carbamazepine Impurity 15 (CAS CATO-C4X-118115)
- Carbamazepine Impurity 19 (CAS CATO-C4X-118119)
- Carbamazepine Impurity 24 (CAS CATO-C4X-118124)
- Carbamazepine EP Impurity G (CAS 59690-97-0)
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- Carbamazepine Impurity 16 (CAS CATO-C4X-118116)
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