3-(1-(4-(Difluoromethoxy)phenyl)-2,5-dimethyl-1H-pyrrol-3-yl)acrylic acid CAS 924876-60-8
| CAS No. | 924876-60-8 |
| Molecular Formula | C16H15F2NO3 |
| Molecular Weight | 307.29 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 3-(1-(4-(Difluoromethoxy)phenyl)-2,5-dimethyl-1H-pyrrol-3-yl)acrylic acid is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
3-(1-(4-(Difluoromethoxy)phenyl)-2,5-dimethyl-1H-pyrrol-3-yl)acrylic acid (CAS 924876-60-8) is a high-purity analytical reference standard with the molecular formula C16H15F2NO3 and a molecular weight of 307.29 g/mol.
3-(1-(4-(Difluoromethoxy)phenyl)-2,5-dimethyl-1H-pyrrol-3-yl)acrylic acid (C16H15F2NO3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 3-(1-(4-(Difluoromethoxy)phenyl)-2,5-dimethyl-1H-pyrrol-3-yl)acrylic acid under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C16H15F2NO3 |
| Molecular Weight | 307.29 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Difluoromethoxy Standards
- 2-(2-(Difluoromethoxy)-7-methylquinoxalin-5-yl)-4-methylthiazole (CAS 2172977-17-0)
- n-{[4-(difluoromethoxy)phenyl]methyl}adamantan-1-amine (CAS 775314-82-4)
- 2-(Difluoromethoxy)-3-(3-fluorophenyl)-5-(trifluoromethyl)pyridine (CAS 1214330-64-9)
- 2-(Difluoromethoxy)-3-(4-fluorophenyl)-5-(trifluoromethyl)pyridine (CAS 1214371-05-7)
- 2-(Difluoromethoxy)-3-(2-fluorophenyl)-5-(trifluoromethyl)pyridine (CAS 1214379-69-7)
- 4-[2,4-bis(difluoromethoxy)phenyl]-1,3-thiazol-2-amine (CAS 757178-55-5)
- 4-(Difluoromethoxy)-2-fluoro-4'-(trifluoromethyl)-1,1'-biphenyl (CAS 1261440-14-5)
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Recommended Standards
- 2-{[({[3-(trifluoromethyl)phenyl]methyl}carbamoyl)methyl]sulfanyl}acetic acid (CAS 338953-72-3)
- Ethyl 2-{[4-cyano-1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]sulfanyl}propanoate (CAS 324009-04-3)
- 1-(2-(Butylselanyl)-3-phenylcyclobut-2-en-1-yl)ethanone (CAS 820963-08-4)
- Methyl 2-[(trifluoroacetyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate (CAS 297743-78-3)
- 6-Chloro-2-methylimidazo[2,1-b][1,3,4]thiadiazole (CAS 189116-10-7)
- 3-(3-(Difluoromethyl)phenyl)propanal (CAS 1806402-04-9)
- n-{1,4-dioxaspiro[4.5]decan-8-ylidene}hydroxylamine (CAS 180918-12-1)
- N,N'-2-Boc-N,N'-bis(2-hydroxyethyl) ethylenediamine (CAS 167407-91-2)
- N-(5-phenyl-1H-imidazol-2-yl)acetamide (CAS 160041-64-5)
- Benvitimod impurity 5 (CAS CATO-C4X-24455)
- 2-Ethoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trifluoromethyl)pyridine (CAS 849934-84-5)
- (3S)-3-phenylpiperazine-2,5-dione (CAS 134521-82-7)
- 2-Amino-3-(2-chloro-5-fluorophenyl)propanoic acid (CAS 1259958-87-6)
- Semaglutide impurity 41 (CAS CATO-C4X-222641)
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