Phenylephrine Impurity 48 CAS 925430-39-3
| CAS No. | 925430-39-3 |
| Molecular Formula | C8H9ClO2 |
| Molecular Weight | 172.61 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 172.61 g/mol gives Phenylephrine Impurity 48 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Phenylephrine Impurity 48 (CAS 925430-39-3), a pharmacopoeial impurity reference standard (molecular formula C8H9ClO2, MW 172.61 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Phenylephrine Impurity 48 (C8H9ClO2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Phenylephrine Impurity 48 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H9ClO2 |
| Molecular Weight | 172.61 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
Related Phenylephrine Standards
- Phenylephrine Impurity 57 (CAS 1477-63-0)
- L-Phenylephrine (CAS 59-42-7)
- Phenylephrine Impurity 46 (CAS 54-06-8)
- Phenylephrine Impurity 100 (CAS 1026633-55-5)
- Phenylephrine 4,6-DMTQ Impurity(Peak-1) (CAS 23824-24-0)
- Phenylephrine 4,6-DMTQ Impurity(Peak-2) (CAS 23824-25-1)
- Phenylephrine Impurity 35 (CAS 57236-57-4)
- Phenylephrine Impurity N21 (CAS 2292095-11-3)
Recommended Standards
- Vildagliptin Impurity 11 (CAS 207557-35-5)
- Tulobuterol Impurity 4 (CAS 59365-60-5)
- Vildagliptin Impurity 10 (CAS 565452-98-4)
- Phloroglucinol Impurity 14 (CAS 7051-16-3)
- LCZ-696 Impurity 66 (CAS 153037-40-2)
- Tofacitinib Impurity 127 (CAS 1204176-45-3)
- Methylnaltrexone Bromide Impurity 13 (CAS CATO-C4X-152113)
- Opicapone Impurity 79 (CAS CATO-C4X-240479)
- 3-(4-Ethylphenyl)-1H-pyrazole-4-carboxaldehyde (CAS 350999-89-2)
- 2-(Hydroxymethyl)benzo[d]oxazole-4-carbonyl chloride (CAS 1803812-78-3)
- 2-(Perfluoropropyl)pyrimidine-5-carboxylic acid (CAS 2108663-82-5)
- 2-((4-Oxo-3-(p-tolyl)-3,4-dihydroquinazolin-2-yl)thio)acetohydrazide (CAS 37029-36-0)
- 4-(Furan-2-carbonyl)piperazine-1-carboximidamide sulfate (CAS 1417567-53-3)
- Des-Lys20(Side Chain)-Semaglutide (CAS CATO-C4X-2226280)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com