5-(Difluoromethoxy)-2-methoxybenzenesulfonyl chloride CAS 929341-63-9
| CAS No. | 929341-63-9 |
| Molecular Formula | C8H7ClF2O4S |
| Molecular Weight | 272.65 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
5-(Difluoromethoxy)-2-methoxybenzenesulfonyl chloride (CAS 929341-63-9), molecular formula C8H7ClF2O4S and molecular weight 272.65 g/mol, is a CATO reference standard with documented purity and traceability.
5-(Difluoromethoxy)-2-methoxybenzenesulfonyl chloride (C8H7ClF2O4S) contains a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H7ClF2O4S |
| Molecular Weight | 272.65 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl-containing |
| Sulfur Atoms | 1 |
Related Difluoromethoxy Standards
- 2-(Difluoromethoxy)-5-methoxybenzene-1-sulfonyl chloride (CAS 1154355-35-7)
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- 2-(6-(Difluoromethoxy)-5-methoxy-1h-indazol-3-yl)acetic acid (CAS 1306604-65-8)
- 2-(6-(Difluoromethoxy)-7-methoxy-1h-indazol-3-yl)acetic acid (CAS 1306606-55-2)
- Methyl 4-(3-(difluoromethoxy)phenyl)-2,4-dioxobutanoate (CAS 832741-03-4)
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- 1-Difluoromethoxy-2-nitro-3-(trifluoromethoxy)benzene (CAS 1803825-59-3)
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Recommended Standards
- 4-[2-Chloro-5-(trifluoromethyl)phenyl]phenol (CAS 634192-46-4)
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- N-(4-chlorophenyl)-2-(trifluoromethyl)pyridin-4-amine (CAS 234112-20-0)
- 3-((7-Chloro-4-nitrobenzo[c][1,2,5]oxadiazol-5-yl)amino)propan-1-ol (CAS 372975-34-3)
- Methyl (3S,4R)-1-benzyl-4-(4-chlorophenyl)pyrrolidine-3-carboxylate (CAS 862283-69-0)
- 3-(3-chloro-4-fluorophenyl)-3-oxopropanenitrile (CAS 267880-79-5)
- 3-Bromodihydrofuran-2,5-dione (CAS 5470-44-0)
- Tofacitinib Impurity 129 (CAS 1527525-58-1)
- 3-Morpholinopropane-1-sulfonyl chloride (CAS 103631-63-6)
- 3-Cyano-5-iodobenzoic acid (CAS 453566-16-0)
- 5-(3,5-Dichlorophenyl)pyrimidin-2-amine (CAS 947592-73-6)
- CIS-ETHYL 3-AMINOTETRAHYDRO-2H-PYRAN-4-CARBOXYLATE HCL (CAS 1363405-28-0)
- (S)-2-(4-((tert-Butoxycarbonyl)amino)-2-oxopyrrolidin-1-yl)aceticacid (CAS 135415-24-6)
- [a-Glu](Side chain transposition)- Semaglutide (CAS CATO-C4X-2226111)
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