3-(Difluoromethoxy)-4-methoxybenzenesulfonyl chloride CAS 929341-67-3
| CAS No. | 929341-67-3 |
| Molecular Formula | C8H7ClF2O4S |
| Molecular Weight | 272.65 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO supplies 3-(Difluoromethoxy)-4-methoxybenzenesulfonyl chloride (CAS 929341-67-3), a certified reference material (molecular formula C8H7ClF2O4S, MW 272.65 g/mol) for analytical method development and quality control.
The molecular framework of 3-(Difluoromethoxy)-4-methoxybenzenesulfonyl chloride (C8H7ClF2O4S) is characterized by a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H7ClF2O4S |
| Molecular Weight | 272.65 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl-containing |
| Sulfur Atoms | 1 |
Related Difluoromethoxy Standards
- 2-(Difluoromethoxy)-5-methoxybenzene-1-sulfonyl chloride (CAS 1154355-35-7)
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- Methyl 4-(3-(difluoromethoxy)phenyl)-2,4-dioxobutanoate (CAS 832741-03-4)
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- 1-Difluoromethoxy-2-nitro-3-(trifluoromethoxy)benzene (CAS 1803825-59-3)
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Recommended Standards
- 3-((7-Chloro-4-nitrobenzo[c][1,2,5]oxadiazol-5-yl)amino)propan-1-ol (CAS 372975-34-3)
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- 2-((7-Chloro-4-nitrobenzo[c][1,2,5]oxadiazol-5-yl)(methyl)amino)ethan-1-ol (CAS 376370-18-2)
- 1-(4-Chlorophenoxy)-2-(difluoromethyl)-3-fluorobenzene (CAS 2149602-13-9)
- (Imino(3-(trifluoromethyl)phenyl)methyl)glycine (CAS 338982-13-1)
- 5-Methyl-4-{[(2-thienylmethyl)amino]methylene}-2,4-dihydro-3H-pyrazol-3-one (CAS 240115-97-3)
- 1-Ethyl-2-mercapto-1H-benzoimidazole-5-sulfonic acid diethylamide (CAS 568570-12-7)
- Methyl 5-cyano-2-mercaptobenzoate (CAS 1824581-95-4)
- 3-(1-(6-Chloropyridin-3-yl)cyclobutyl)-5-(1H-pyrazol-4-yl)-1,2,4-oxadiazole (CAS 1369513-95-0)
- 4-[4-(4-chlorophenyl)piperazin-1-yl]-4-oxobutanoic acid (CAS 540521-73-1)
- 1-((4-(2-Chlorophenoxy)phenyl)sulfonamido)cyclohexane-1-carboxylic acid (CAS 885268-82-6)
- Amoxapine Impurity 2 (CAS 2770-11-8)
- 2-Amino-2-(thiophen-3-yl)acetonitrile hydrochloride (CAS 127698-22-0)
- Insulin Degludec Impurity 11 (CAS CATO-C4X-215711)
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