(3,4-Difluoro-5-(2,2,2-trifluoroethoxy)phenyl)boronic acid CAS 936250-24-7
| CAS No. | 936250-24-7 |
| Molecular Formula | C8H6BF5O3 |
| Molecular Weight | 255.93 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
(3,4-Difluoro-5-(2,2,2-trifluoroethoxy)phenyl)boronic acid (CAS 936250-24-7), molecular formula C8H6BF5O3 and molecular weight 255.93 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of (3,4-Difluoro-5-(2,2,2-trifluoroethoxy)phenyl)boronic acid (C8H6BF5O3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H6BF5O3 |
| Molecular Weight | 255.93 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.5 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
Related Difluoro Standards
- [3,5-Difluoro-4-(2,2,2-trifluoroethoxy)phenyl]boronic acid (CAS 160483-71-6)
- [3,5-Difluoro-2-(2,2,2-trifluoroethoxy)phenyl]boronic acid (CAS 936250-26-9)
- 3,5-Difluoro-4-iodophenol (CAS 1000574-74-2)
- 3,5-Difluoro-4-iodopyridin-2-amine (CAS 1325215-07-3)
- 2,3-Difluoro-4-iodophenol (CAS 144292-40-0)
- 4,5-Difluoro-2-iodophenol (CAS 186590-30-7)
- 4,6-Difluoro-2-iodopyridin-3-amine (CAS 1934432-95-7)
- 2,4-Difluoro-5-iodophenol (CAS 1935521-44-0)
Recommended Standards
- 5-(Bromomethyl)-4,6-dichloro-2-methylpyrimidine (CAS 1780-34-3)
- (4-(Difluoromethoxy)-3-(trifluoromethyl)phenyl)boronic acid (CAS 958451-79-1)
- 5-Bromo-3,4-dichlorobenzene-1,2-diamine (CAS 177944-67-1)
- (4-bromo-2,6-dichlorophenyl)hydrazine (CAS 85634-76-0)
- 3-Cyano-4-isobutyloxythiobenzamide (CAS 163597-57-7)
- 3-Bromo-6-(methylsulfonyl)quinoline (CAS 1860894-29-6)
- 3-Nitropentane (CAS 551-88-2)
- Artesunate Impurity 6 (CAS CATO-C4X-15476)
- 1-Cyclopropyl-1H-imidazole-4-carboxylic acid (hydrochloride) (CAS 2044797-07-9)
- b-Hydroxy-4-nitro-phenylalanine (CAS 10098-38-1)
- Chlorphenamine impurity 53 (CAS CATO-C4X-118853)
- Clorprenaline Hydrochloride (CAS 6933-90-0)
- 1,2-Dihydroquinolin-3-amine (CAS 647026-44-6)
- Semaglutide Impurity 246 (CAS CATO-C4X-2226246)
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