[2-(2,2-Difluoroethoxy)-3,5-difluorophenyl]boronic acid CAS 936250-25-8
| CAS No. | 936250-25-8 |
| Molecular Formula | C8H7BF4O3 |
| Molecular Weight | 237.94 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
[2-(2,2-Difluoroethoxy)-3,5-difluorophenyl]boronic acid (CAS 936250-25-8), molecular formula C8H7BF4O3 and molecular weight 237.94 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of [2-(2,2-Difluoroethoxy)-3,5-difluorophenyl]boronic acid (C8H7BF4O3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), [2-(2,2-Difluoroethoxy)-3,5-difluorophenyl]boronic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H7BF4O3 |
| Molecular Weight | 237.94 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.5 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
Related Difluoroethoxy Standards
- (3-(2,2-Difluoroethoxy)-4,5-difluorophenyl)boronic acid (CAS 936250-23-6)
- 4-(2,2-Difluoroethoxy)benzenesulfonamide (CAS 1183965-30-1)
- 2-(3-(2,2-Difluoroethoxy)-4-nitro-1H-pyrazol-1-yl)ethan-1-amine (CAS 1856102-52-7)
- 3-(2,2-Difluoroethoxy)-1-isopropyl-4-nitro-1H-pyrazole (CAS 1429418-58-5)
- 4-(2,2-Difluoroethoxy)-2-trifluoromethylphenylamine (CAS 1242458-44-1)
- 2-(2,2-Difluoroethoxy)-5-(trifluoromethyl)aniline (CAS 937597-00-7)
- 4-(2,2-Difluoroethoxy)-3-(trifluoromethyl)aniline (CAS 924909-23-9)
- 2-(2,2-Difluoroethoxy)quinoline-4-carbonitrile (CAS 1555508-44-5)
Recommended Standards
- (4-Fluoro-3-(2,2,2-trifluoroethoxy)phenyl)boronic acid (CAS 957034-62-7)
- [2-fluoro-4-(2,2,2-trifluoroethoxy)phenyl]boronic acid (CAS 2246556-71-6)
- (4-Ethoxy-2,3,5,6-tetrafluorophenyl)boronic acid (CAS 871125-72-3)
- 2,2,6,6-Tetrachlorocyclohexanol (CAS 56207-45-5)
- N,N-Dimethyl-N'-(3-methylpyridin-2-yl)formimidamide (CAS 36172-55-1)
- Octafluorobutan-2-one (CAS 337-20-2)
- 3-(Cyclohexylmethyl)-5-{[(3-fluorophenyl)methyl]sulfanyl}-8,9-dimethoxy-2H,3H-imidazo[1,2-c]quinazolin-2-one (CAS 1024620-09-4)
- (R)-Tetrahydro-3H-oxazolo[3,4-a]pyridine-3,7(1H)-dione (CAS 1226594-79-1)
- 1-Diethoxyphosphoryl-4-ethoxy-benzene (CAS 176251-04-0)
- (4-Cyclopropylthiophen-2-yl)methanol (CAS 2416262-91-2)
- 3-Hydroxy-2-(3-hydroxyphenyl)prop-2-enal (CAS 105899-68-1)
- tert-Butyl 3-cyclobutyl-4-oxopiperidine-1-carboxylate (CAS 1425336-37-3)
- Nabumetone EP Impurity D (CAS 127053-22-9)
- Acetyl-Exenatide trifluoroacetate salt (CAS 305815-28-5)
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