Apixaban Impurity N2 CAS 940-11-4
| CAS No. | 940-11-4 |
| Molecular Formula | C8H10N2O2 |
| Molecular Weight | 166.18 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Apixaban Impurity N2 (C8H10N2O2) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Apixaban Impurity N2 (CAS 940-11-4) is a certified pharmaceutical impurity reference standard with the molecular formula C8H10N2O2 and a molecular weight of 166.18 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Apixaban Impurity N2 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H10N2O2 |
| Molecular Weight | 166.18 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 2 |
Related Apixaban Standards
- Apixaban Impurity 67 (CAS 2323-81-1)
- Apixaban Impurity 37 (CAS 99585-01-0)
- Apixaban Impurity 94 (CAS 813452-05-0)
- Apixaban Impurity 38 (CAS CATO-C4X-108838)
- Apixaban Impurity 182 (CAS CATO-C4X-1088182)
- Apixaban Impurity 85 (CAS 14273-86-0)
- Apixaban Impurity 92 (CAS 2403-63-6)
- Apixaban Impurity 35 (CAS 2285-12-3)
Recommended Standards
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- 4-(Mercapto(phenyl)methyl)phenol (CAS 1038981-79-1)
- Cyclobutyl 4-(piperidinomethyl)phenyl ketone (CAS 898775-73-0)
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