5-(3-(Trifluoromethyl)phenyl)pyrimidin-2-amine CAS 947592-40-7
| CAS No. | 947592-40-7 |
| Molecular Formula | C11H8F3N3 |
| Molecular Weight | 239.20 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies 5-(3-(Trifluoromethyl)phenyl)pyrimidin-2-amine (CAS 947592-40-7), a certified reference material (molecular formula C11H8F3N3, MW 239.20 g/mol) for analytical method development and quality control.
The molecular framework of 5-(3-(Trifluoromethyl)phenyl)pyrimidin-2-amine (C11H8F3N3) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 5-(3-(Trifluoromethyl)phenyl)pyrimidin-2-amine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H8F3N3 |
| Molecular Weight | 239.20 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Trifluoromethyl Standards
- 2-(4-(Trifluoromethyl)phenyl)pyrimidin-5-amine (CAS 1094311-67-7)
- 5-(4-(Trifluoromethyl)phenyl)pyrimidin-2-amine (CAS 1111104-89-2)
- 5-(2-(Trifluoromethyl)phenyl)pyrimidin-2-amine (CAS 1111105-09-9)
- 6-(4-(Trifluoromethyl)phenyl)pyrazin-2-amine (CAS 1159819-32-5)
- 6-(4-(Trifluoromethyl)phenyl)pyridazin-3-amine (CAS 1215073-83-8)
- 5-(Trifluoromethyl)-[2,3'-bipyridin]-5'-amine (CAS 1255634-59-3)
- 6-(3-(Trifluoromethyl)phenyl)pyrimidin-4-amine (CAS 1482437-88-6)
- 2-(3-(Trifluoromethyl)phenyl)pyrimidin-5-amine (CAS 827322-74-7)
Recommended Standards
- 4-(4-(Trifluoromethyl)phenyl)pyrimidin-2-amine (CAS 916792-24-0)
- 5-[3-(Trifluoromethyl)phenyl]pyrazin-2-amine (CAS 59489-74-6)
- 4-(3-(Trifluoromethyl)phenyl)pyrimidin-2-amine (CAS 866019-76-3)
- Ethyl (E)-3-(2-fluoro-5-nitrophenyl)acrylate (CAS 91319-50-5)
- 2-((3-Formyl-1H-indol-1-yl)methyl)benzonitrile (CAS 340319-15-5)
- (2R,3R,4S,5R,6R)-2-(acetoxymethyl)-6-(2-bromoethoxy)tetrahydro-2H-pyran-3,4,5-triyl triacetate (CAS 16977-78-9)
- 2,3-Dibromo-5-cyclopropoxypyridine (CAS 1243387-22-5)
- 2-Fluoro-5-(trifluoromethyl)cinnamic acid (CAS 247113-91-3)
- 3-Methyl-4'-(pyrrolidin-1-ylsulfonyl)-[1,1'-biphenyl]-2-carboxylic acid (CAS 1262007-21-5)
- Ethyl 2-((4-aminocyclohexyl)oxy)acetate (CAS 1564649-71-3)
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