1-(2,6-Difluorobenzoyl)piperidin-4-one CAS 948853-53-0
| CAS No. | 948853-53-0 |
| Molecular Formula | C12H11F2NO2 |
| Molecular Weight | 239.22 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
1-(2,6-Difluorobenzoyl)piperidin-4-one (CAS 948853-53-0) is a high-purity analytical reference standard with the molecular formula C12H11F2NO2 and a molecular weight of 239.22 g/mol.
1-(2,6-Difluorobenzoyl)piperidin-4-one (C12H11F2NO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO manufactures 1-(2,6-Difluorobenzoyl)piperidin-4-one under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C12H11F2NO2 |
| Molecular Weight | 239.22 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Difluorobenzoyl Standards
- 1-(2,6-Difluorobenzoyl)azepane (CAS 385380-70-1)
- 1-(3,4-Difluorobenzoyl)-1,4-diazepane (CAS 1016683-49-0)
- 1-(3,5-Difluorobenzoyl)-1,4-diazepane (CAS 1016704-74-7)
- 1-(2,5-Difluorobenzoyl)-1,4-diazepane (CAS 1016800-39-7)
- 1-(2,4-Difluorobenzoyl)-3-methylpiperazine (CAS 1240564-71-9)
- 1-(2,5-Difluorobenzoyl)-3-methylpiperazine (CAS 1240564-77-5)
- 1-(3,4-Difluorobenzoyl)-3-methylpiperazine (CAS 1240564-95-7)
- 1-(2,5-Difluorobenzoyl)-2-methylpiperazine (CAS 1240565-38-1)
Recommended Standards
- (S)-3-(((benzyloxy)carbonyl)amino)-2-hydroxypropanoic acid (CAS 42491-79-2)
- 1-(4,5-Dimethoxy-2-nitrophenyl)propan-1-one (CAS 91134-62-2)
- (S)-2-(tert-Butoxycarbonylamino)-4,4-difluorobutanoic acid (CAS 467442-20-2)
- 1,12-Dichlorododecane (CAS 3922-28-9)
- 2-(Trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-6-carbaldehyde (CAS 1224587-26-1)
- 2-Bromo-5-fluorophenyl Isothiocyanate (CAS 1027513-65-0)
- 5-(1H-Pyrrol-2-yl)-1H-1,2,4-triazol-3-amine (CAS 502546-40-9)
- 3-Cyclopropyl-2-thioxo-1,3-diazaspiro[4.5]Decan-4-one (CAS 832741-02-3)
- 5-Bromoisoquinolin-3(2H)-one (CAS 1175271-86-9)
- 3-nitronaphthalene-1-carboxylic acid (CAS 4507-84-0)
- 2-(Cyclopropylmethyl)-6-ethyl-3H,4H-thieno[2,3-d]pyrimidin-4-one (CAS 1788637-72-8)
- 5-[(4-Chlorophenyl)methanesulfonyl]-4-methyl-1,2,3-thiadiazole (CAS 400086-11-5)
- 5-Methoxy-1,2,3,4-tetrahydropyrido[3,4-b]pyrazine (CAS 1936245-13-4)
- Semaglutide Impurity 183 (CAS 159541-28-3)
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