2-Amino-4-chloro-6-(trifluoromethyl)pyrimidine-5-carbonitrile CAS 951753-89-2
| CAS No. | 951753-89-2 |
| Molecular Formula | C6H2ClF3N4 |
| Molecular Weight | 222.56 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 2-Amino-4-chloro-6-(trifluoromethyl)pyrimidine-5-carbonitrile is closely related to a nitrile group, fluorine/chlorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies 2-Amino-4-chloro-6-(trifluoromethyl)pyrimidine-5-carbonitrile (CAS 951753-89-2), a certified reference material (molecular formula C6H2ClF3N4, MW 222.56 g/mol) for analytical method development and quality control.
The molecular framework of 2-Amino-4-chloro-6-(trifluoromethyl)pyrimidine-5-carbonitrile (C6H2ClF3N4) is characterized by a nitrile group, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H2ClF3N4 |
| Molecular Weight | 222.56 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related Amino Standards
- 4-Amino-3-chloro-6-(difluoromethyl)picolinic acid (CAS 1796589-44-0)
- 6-Amino-3-chloro-5-(difluoromethyl)picolinic acid (CAS 1803668-45-2)
- 2-Amino-6-chloro-4-(difluoromethyl)nicotinic acid (CAS 1803668-49-6)
- 4-Amino-6-chloro-3-(difluoromethyl)pyridine-2-carboxylic acid (CAS 1804451-66-8)
- 4-Amino-6-chloro-5-(difluoromethyl)picolinic acid (CAS 1805008-61-0)
- 6-Amino-4-chloro-5-(difluoromethyl)picolinic acid (CAS 1805061-78-2)
- 6-Amino-2-chloro-5-(difluoromethyl)nicotinic acid (CAS 1805061-87-3)
- 2-Amino-6-chloro-5-(difluoromethyl)nicotinic acid (CAS 1805100-86-0)
Recommended Standards
- 8-Chloro-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine (CAS 140911-31-5)
- 2-Chloro-6-(trifluoromethyl)-9H-purine (CAS 1998-64-7)
- 6-Chloro-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine (CAS 1379310-87-8)
- 5-Chloro-2-(trifluoromethyl)-[1,2,4]triazolo[1,5-c]pyrimidine (CAS 877402-89-6)
- Cyclohexyl 3-(4-bromophenyl)-3-(phenylsulfonyl)propanoate (CAS 2376300-23-9)
- 1,1,1-trifluoro-4-methoxy-2-methylbutan-2-ol (CAS 1248603-13-5)
- 1-(2-Methoxyphenyl)-3-{1-[3-(pyrazin-2-yl)-1,2,4-oxadiazol-5-yl]cyclohexyl}urea (CAS 1396766-54-3)
- 4-Methoxy-[1,1'-biphenyl]-3-carboxylic acid (CAS 107410-07-1)
- Ethyl 3-[4-(benzyloxy)phenyl]-3-oxopropanoate (CAS 53090-45-2)
- N,N-Di-tert-butoxycarbonyl-benzene-1,3-diamine (CAS 883554-89-0)
- N1-Phenyl-N2-(pyridin-2-ylmethyl)oxalamide (CAS 352013-06-0)
- Ticagrelor Impurity 88 (CAS 1006376-61-9)
- 5-(1-Phenylpropyl)-1,3,4-thiadiazol-2-amine (CAS 299441-79-5)
- Semaglutide impurity 99 (CAS CATO-C4X-222699)
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