Ticagrelor Impurity 88 CAS 1006376-61-9
| CAS No. | 1006376-61-9 |
| Molecular Formula | C12H12F2O2 |
| Molecular Weight | 226.22 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 226.22 g/mol gives Ticagrelor Impurity 88 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Ticagrelor Impurity 88 (CAS 1006376-61-9) is a certified pharmaceutical impurity reference standard with the molecular formula C12H12F2O2 and a molecular weight of 226.22 g/mol.
Based on its molecular formula C12H12F2O2, Ticagrelor Impurity 88 contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 226.22 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H12F2O2 |
| Molecular Weight | 226.22 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | F-containing |
Related Ticagrelor Standards
- Ticagrelor Impurity 100 (CAS 39856-08-1)
- Ticagrelor Impurity 121 (CAS 378236-67-0)
- Ticagrelor Impurity 62 (CAS CATO-C4X-109362)
- Ticagrelor Impurity 124 (CAS 1401318-10-2)
- Ticagrelor Impurity 123 (CAS 33097-11-9)
- Ticagrelor Impurity 43 (CAS 145783-13-7)
- Ticagrelor Impurity 158 (CAS 1402150-27-9)
- Ticagrelor Impurity 23 (CAS CATO-C4X-109323)
Recommended Standards
- 2-Thenoyltrifluoroacetone 326-91-0 1,1,1-TRIFLUORO-3-(2'-THENOYL)ACETONE;1,3-BUTANEDIONE, 4,4,4-TRIFLUORO-1-(2-THIENYL)-;1-(2-THENOYL)-3,3,3-TRIFLUOROACETONE;1-THIEN-2-YL-4,4,4-TRIFLUOROBUTANE-1,3-DIONE;1-THIENYL-4,4,4-TRIFLUORO-1,3-BUTANEDIONE;2,4-DIOXO-4-(THIEN-2-YL)-1,1,1-TRIFLUOROBUTANE;2-(3-OXO-4,4,4-TRIFLUOROBUTANOYL)THIOPHENE;2-(4,4,4-TRIFLUOROACETOACETYL)THIOPHENE;2-THENOYLTRIFLUOROACETONE;4,4,4-TRIFLUORO-1-(2-THENOYL)-1,3-BUTANEDIONE;4,4,4-TRIFLUORO-1-(2-THIENYL)-1,3-BUTANEDIONE;4,4,4-TRIFLUORO-1-(2-THIENYL)BUTANE-1,3-DIONE;4,4,4-TRIFLUORO-1-(THIOPHEN-2-YL)BUTANE-1,3-DIONE;4,4,4-TRIFLUORO-1-THIEN-2-YLBUTANE-1,3-DIONE;4,4-TRIFLUORO-1-(2-THIENYL)-1,3-BUTANEDIONE;HTTA;THENOYLTRIFLUOROACETONE;TTA;TTA (EXTRACTANT);TTB;TTFA SC11823 (CAS 326-91-0)
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