Prednisolone impurity 57 CAS 95671-46-8
| CAS No. | 95671-46-8 |
| Molecular Formula | C20H26O5 |
| Molecular Weight | 346.42 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 346.42 g/mol gives Prednisolone impurity 57 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Prednisolone impurity 57 (CAS 95671-46-8) is a certified pharmaceutical impurity reference standard with the molecular formula C20H26O5 and a molecular weight of 346.42 g/mol.
The molecular framework of Prednisolone impurity 57 (C20H26O5) is characterized by a flavonoid core, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H26O5 |
| Molecular Weight | 346.42 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1984 |
Related Prednisolone Standards
- Prednisolone Impurity 22 (CAS 37927-29-0)
- Prednisolone EP Impurity J (CAS 1807-14-3)
- Prednisolone impurity 54 (CAS CATO-C4X-173754)
- Prednisolone EP Impurity I (CAS 13479-38-4)
- Prednisolone Acetate EP Impurity D (CAS 20423-99-8)
- Prednisolone Impurity 52 (CAS 118864-87-2)
- Prednisolone Impurity 28 (CAS CATO-C4X-191928)
- Prednisolone EP Impurity H (CAS 2427-64-7)
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- 4-(2-(4-Aminophenyl)acetamido)benzene-1-sulfonyl fluoride (CAS 19188-73-9)
- 7-Bromo-4-methyl-6-(trifluoromethyl)phthalazin-1(2H)-one (CAS 2654747-33-6)
- 1,3-Bis(2,2-dimethyl-1,3-dioxolan-4-ylmethyl)carbodiimide (CAS 159390-26-8)
- 4-Hydroxy-6-methyl-3-nitro-2H-pyrano[3,2-c]quinoline-2,5(6H)-dione (CAS 161185-52-0)
- Des-Ser39-Tirzepatide (CAS CATO-CPTD788936)
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