Prednisolone Impurity 28 CAS CATO-C4X-191928
| CAS No. | CATO-C4X-191928 |
| Molecular Formula | C21H26O4 |
| Molecular Weight | 342.43 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Prednisolone Impurity 28 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Prednisolone Impurity 28 (CAS CATO-C4X-191928, C21H26O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Prednisolone Impurity 28 (C21H26O4) is characterized by a flavonoid core, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C21H26O4 |
| Molecular Weight | 342.43 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
Related Prednisolone Standards
- Prednisolone Impurity 52 (CAS 118864-87-2)
- Prednisolone EP Impurity J (CAS 1807-14-3)
- Prednisolone impurity 54 (CAS CATO-C4X-173754)
- Prednisolone EP Impurity I (CAS 13479-38-4)
- Prednisolone Acetate EP Impurity D (CAS 20423-99-8)
- Prednisolone Impurity 22 (CAS 37927-29-0)
- Prednisolone impurity 57 (CAS 95671-46-8)
- Prednisolone Impurity N6 (CAS 75448-51-0)
Recommended Standards
- Peramivir Impurity 69 (CAS CATO-C4X-183369)
- Ketotifen Impurity 16 (CAS CATO-C4X-204616)
- Peramivir Impurity 43 (CAS 229614-51-1)
- Relebactam Impurity 20 (CAS CATO-C4X-214420)
- Ethacridine Impurity C53 (CAS 20304-70-5)
- Vazegepant Impurity 14 (CAS 928014-62-4)
- Dapoxetine Impurity 13 (CAS 94305-25-6)
- 5-(3-Nitrophenyl)oxazol-2-amine (CAS 933053-34-0)
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- 5-Iodo-2-methylbenzyl Alcohol (CAS 1260242-01-0)
- 5',5''-Bis(4-carboxyphenyl)-4'',6'-dimethoxy-[1,1':3',1'':3'',1'''-quaterphenyl]-4,4'''-dicarboxylicacid (CAS 1931172-14-3)
- 2-Hydroxy-4-(prop-2-yn-1-yloxy)benzaldehyde (CAS 67268-54-6)
- N-(2,3-Difluorobenzyl)-1-(2,2-difluoroethyl)-1H-pyrazol-4-amine hydrochloride (CAS 1856051-99-4)
- Tirzepatide Impurity 10 (CAS CATO-C4X-324010)
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