Naltrexone EP Impurity I CAS 96445-14-6
| CAS No. | 96445-14-6 |
| Molecular Formula | C20H21NO5 |
| Molecular Weight | 355.38 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Naltrexone EP Impurity I (CAS 96445-14-6, C20H21NO5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C20H21NO5, Naltrexone EP Impurity I contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 355.38 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H21NO5 |
| Molecular Weight | 355.38 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1984 |
| Nitrogen Atoms | 1 |
Related Naltrexone Standards
- Naltrexone EP Impurity J (CAS 16617-07-5)
- Naltrexone Impurity 16 (CAS CATO-C4X-147516)
- Naltrexone Impurity N4 (CAS 16676-33-8)
- Naltrexone Impurity 19 (CAS 112269-62-2)
- Naltrexone EP Impurity F (CAS 2397651-97-5)
- Naltrexone Impurity 61 (CAS CATO-C4X-147561)
- Naltrexone EP Impurity G (CAS CATO-C4X-14757)
- Naltrexone impurity 41 (CAS CATO-C4X-147541)
Recommended Standards
- 2-[3-(3,4-Dimethoxy-phenyl)-acryloylamino]-benzoic acid 53902-17-3 (CAS 53902-17-3)
- Naloxone Impurity 19 (CAS CATO-C4X-149319)
- Repirinast (CAS 73080-51-0)
- Ketorolac Impurity 37 (CAS CATO-C4X-166937)
- Terbutaline impurity 101 (CAS 1226543-90-3)
- Etoposide EP Impurity Q (CAS 153975-26-9)
- Vildagliptin Impurity 81 (CAS CATO-C4X-110081)
- 9002-83-9 Chlorotrifluoroethene, homopolymer Ethene, chlorotrifluoro-, homopolymer Polychlorotrifluoroethylene Ethylene, chlorotrifluoro-, polymers (8CI) Halocarbon oil, series 27-S Kel-F Safetol 3.1 oil Ethene, 1-chloro-1,2,2-trifluoro-, homopolymer F 3M 11 F 12 F 12FD 13FM 4LF F 3 (Vinyl polymer) 3.1 Oil Aclar 22A Aclar 33C Chlorotrifluoroethene homopolymer Chlorotrifluoroethylene homopolymer Chlorotrifluoroethylene polymer Chlorotrifluoroethylene polymers Daifloil 10 Daifloil 100 Daifloil 20 Daifloil 3 Daifloil 50 Daiflon D 45S Daiflon M 300 Daiflon M 300P Daiflon ctf3-D 55P Daiflon ctfe Ekafluvin FL-G 100 FL-G 330 FL-G 35 FL-G 5 Fluorolon 3 Fluorolube S 30 Fluorolube 2000 Fluorolube 300/140 Fluorolube FS 5 Fluorolube GR 470 Fluoroplast F 3 Fluoroplast 3 Fluoroplast 3P Fluorothene Ftorlon F3 Ftorlon 3 Ftorlon 3M Ftoroplast 3 Ftoroplast 3P Halar 200 Halocarbon 3.1 oil Halocarbon oil 11-14 Halocarbon oil 11-21 Halocarbon oil 13-21 Halon Halon (polymer) Hostaflon Hostaflon C Kel-F 200 Kel-F 3 Kel-F 6061 Kel-F 81 Kel-F 90 Kel-F 95/5 Kel-S Mil-H-531119 MLO 81-125 MLO 83-322 MLO 87-347 Neosorb ND Plaskon CTFE Poly(chlorotrifluoroethene) Poly(monochlorotrifluoroethylene) Poly(trifluorochloroethylene) Poly(trifluoroethylene chloride) Poly(trifluoromonochloroethylene) Poly(trifluorovinyl chloride) Teflex TL 340 Trifluorochloroethylene polymer Voltalef Voltalef 10 Voltalef 202 Voltalef 300LD Voltalef 300UF Voltalef IS (CAS 9002-83-9)
- (R)-2-((tert-butoxycarbonyl)amino)-3-(5-chloro-1H-indol-3-yl)propanoic acid (CAS 114903-31-0)
- 4-(2-Hydroxyethyl)tetrahydro-2H-thiopyran 1,1-dioxide (CAS 1782025-98-2)
- 4-Bromo-2-(difluoromethyl)-5-(trifluoromethyl)pyridin-3-ol (CAS 1805239-90-0)
- 4-((6-Chloro-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy)-3,5-difluoroaniline (CAS 1203656-90-9)
- N-[4-(2-{[(2,2-Dimethyl-4,6-dioxo-1,3-dioxan-5-yliden)methyl]amino}-1,3-thiazol-4-yl)phenyl]acetamide (CAS 497060-17-0)
- Insulin Degludec Impurity 2 (CAS CATO-C4X-21572)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com