Betamethasone Impurity 26 CAS 98574-03-9
| CAS No. | 98574-03-9 |
| Molecular Formula | C22H26O2 |
| Molecular Weight | 322.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Betamethasone Impurity 26 (CAS 98574-03-9, C22H26O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C22H26O2, Betamethasone Impurity 26 contains a steroid core, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 322.44 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H26O2 |
| Molecular Weight | 322.44 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
Related Betamethasone Standards
- Betamethasone Impurity 10 (CAS 38680-83-0)
- Betamethasone Impurity 78 (CAS CATO-C4X-143778)
- Betamethasone Impurity 126 (CAS 90039-84-2)
- Betamethasone Impurity 81 (CAS CATO-C4X-143781)
- Betamethasone Impurity 66 (CAS 90039-90-0)
- Betamethasone EP Impurity C (CAS 13504-15-9)
- Betamethasone EP Impurity F (CAS 330157-04-5)
- Betamethasone Impurity 94 (CAS 19784-87-3)
Recommended Standards
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- Fudosteine Impurity 34 (CAS CATO-C4X-144734)
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- Propofol Impurity 28 (CAS 40388-51-0)
- Salbutamol Impurity N19 (CAS 77430-27-4)
- Prucalopride Impurity 4 (CAS CATO-C4X-10384)
- Citalopram EP Impurity M (CAS 440121-09-5)
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- 5-Bromo-6-(cyclohexyloxy)nicotinic acid (CAS 1216394-54-5)
- 2-Methylthio-3-isopropylpyrazine (CAS 67952-59-4)
- 2-(tert-Butyl)-6-chlorobenzo[d]oxazole-7-thiol (CAS 954127-39-0)
- Propyl 4-methylbenzoate (CAS 6976-69-8)
- 7-tert-Butyl-2-mercapto-3-phenyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one (CAS 312625-72-2)
- Acetyl-Tau Peptide (244-274) (Repeat 1 Domain) trifluoroacetate salt (CAS 2022956-56-3)
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