Ibrutinib Impurity N34 CAS 98977-36-7
| CAS No. | 98977-36-7 |
| Molecular Formula | C10H17NO3 |
| Molecular Weight | 199.25 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Ibrutinib Impurity N34 (CAS 98977-36-7, C10H17NO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Ibrutinib Impurity N34 (C10H17NO3) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 3.0, corresponding to approximately 3 ring(s) or double-bond equivalent(s). With a molecular weight of 199.25 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Ibrutinib Impurity N34 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H17NO3 |
| Molecular Weight | 199.25 g/mol |
| Appearance | White to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1985 |
| Nitrogen Atoms | 1 |
Related Ibrutinib Standards
- Ibrutinib Impurity 6 (CAS 143900-44-1)
- Ibrutinib Impurity 80 (CAS 109384-19-2)
- Ibrutinib Impurity N9 (CAS 86953-81-3)
- Ibrutinib Impurity 98 (CAS CATO-C4X-106498)
- Ibrutinib Impurity N2 (CAS 43191-23-7)
- Ibrutinib Impurity 54 (CAS 1260862-85-8)
- Ibrutinib Impurity 193 (CAS 60034-89-1)
- Ibrutinib Impurity 79 (CAS 21218-94-0)
Recommended Standards
- Agomelatine Impurity N10 (CAS 861960-34-1)
- 2,4-Diaminodiphenylamine (CAS 136-17-4)
- Pyrimethanil (CAS 53112-28-0)
- 4-Methylbenzophenone D3 (CAS 109339-64-2)
- Crizotinib Impurity 01 (CAS 877399-51-4)
- Salcaprozate Impurity N1 (CAS 20073-95-4)
- Trazodone impurity 41 (CAS CATO-C4X-177241)
- 1-Boc-4-methylpiperidine-4-carboxamide (CAS 343788-67-0)
- 3-(Aminomethyl)-4-bromo-1-methyl-1H-pyrazole-5-carboxylic acid hydrobromide (CAS 2137604-66-9)
- (S)-7-azaspiro[3.5]Nonan-1-amine (CAS 2055848-58-1)
- 1-(3,4,5-Trichlorophenyl)ethanone (CAS 35981-65-8)
- (2,5-Dimethylhexane-1,6-diyl)bis(trichlorosilane) (CAS 18290-90-9)
- 2-Chloro-7-(trifluoromethoxy)quinoline (CAS 1352443-25-4)
- Neuropeptide EI (human, mouse, rat) (CAS 125934-45-4)
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