Erythromycin EP Impurity B CAS 992-62-1
| CAS No. | 992-62-1 |
| Molecular Formula | C36H65NO13 |
| Molecular Weight | 719.90 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Erythromycin EP Impurity B (CAS 992-62-1, C36H65NO13) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C36H65NO13, Erythromycin EP Impurity B contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 719.90 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C36H65NO13 |
| Molecular Weight | 719.90 g/mol |
| Purity | >90% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 1 |
Related Erythromycin Standards
- Erythromycin C (CAS 1675-02-1)
- Erythromycin 4’- (CAS 200802-92-2)
- Erythromycin thiocyanate impurity B reduced derivative (CAS CATO-C4X-100166)
- Erythromycin C reduced derivatives (CAS CATO-C4X-100169)
- Erythromycin B (CAS 527-75-3)
- Erythromycin C rearranged derivatives (CAS CATO-C4X-100171)
- Erythromycin thiocyanate impurity B rearranged derivative (CAS CATO-C4X-100174)
- Erythromycin EP Impurity E (CAS 33396-29-1)
Recommended Standards
- Argatroban Impurity 114 (CAS CATO-C4X-1007114)
- (R,E)-2-((11-Carboxy-9-oxoundec-10-enoyl)oxy)-3-(palmitoyloxy)propyl (2-(trimethylammonio)ethyl) phosphate (CAS 439904-34-4)
- DBCO-PEG4-Desthiobiotin (CAS 2032788-37-5)
- Azithromycin EP Impurity N (CAS 612069-25-7)
- Progesterone Impurity N38 (CAS 70081-51-5)
- Ulipristal Impurity 30 (CAS 1383782-13-5)
- Isavuconazole Impurity 53 (CAS CATO-C4X-123653)
- (2S,4R)-Methyl 4-amino-1-methylpyrrolidine-2-carboxylate (CAS 1256636-22-2)
- (2R,3S)-3-(3-Methoxyphenyl)pyrrolidine-2-carboxylic acid (CAS 1391458-04-0)
- 7470-51-1 9136AE C11H13NO2 N-(4-Acetylphenyl)propanamide (CAS 7470-51-1)
- (S)-1-(2-((2-(5-Methyl-2-phenyloxazol-4-yl)ethyl)amino)acetyl)pyrrolidine-2-carbonitrile (CAS 521266-46-6)
- Hydrocortisone impurity 40 (CAS 33767-18-9)
- 3-(3-Methoxyphenyl)-5-methyl-4,5-dihydro-1,2-oxazole-5-carboxylic acid (CAS 1326811-79-3)
- D-Ser32-Tirzepatide (CAS CATO-CPTD788692)
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