Hydrocortisone impurity 40 CAS 33767-18-9
| CAS No. | 33767-18-9 |
| Molecular Formula | C25H32O8 |
| Molecular Weight | 460.52 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Hydrocortisone impurity 40 (CAS 33767-18-9, C25H32O8) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C25H32O8, Hydrocortisone impurity 40 contains a flavonoid core, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 460.52 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C25H32O8 |
| Molecular Weight | 460.52 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1966 |
Related Hydrocortisone Standards
- Hydrocortisone Impurity 01 (CAS 10215-75-5)
- Hydrocortisone Impurity 60 (CAS CATO-C4X-140160)
- Hydrocortisone Impurity 61 (CAS CATO-C4X-140161)
- Hydrocortisone 17-Propionate 21-Acetate (CAS 74050-20-7)
- Hydrocortisone Impurity 39 (CAS 3593-96-2)
- Hydrocortisone Impurity 32 (CAS 103242-89-3)
- Hydrocortisone Impurity 67 (CAS 146201-55-0)
- Hydrocortisone Impurity 75 (CAS 220489-73-6)
Recommended Standards
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