Agomelatine Impurity 19 CAS 99416-97-4
| CAS No. | 99416-97-4 |
| Molecular Formula | C15H20O4 |
| Molecular Weight | 264.32 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Agomelatine Impurity 19 (CAS 99416-97-4, C15H20O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Agomelatine Impurity 19 (C15H20O4) contains a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 264.32 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H20O4 |
| Molecular Weight | 264.32 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
Related Agomelatine Standards
- Agomelatine Impurity 7 (CAS 166526-99-4)
- Agomelatine Impurity 28 (CAS CATO-C4X-110828)
- Agomelatine Impurity 32 (CAS 138112-79-5)
- Agomelatine Impurity 53 (CAS CATO-C4X-110853)
- Agomelatine-d6 (CAS 1079389-42-6)
- Agomelatine Impurity 35 (CAS 178677-49-1)
- Agomelatine-D3 (CAS 107389-38-0)
- Agomelatine Impurity 19 (CAS 1352139-51-5)
Recommended Standards
- 8-(4-Methoxyphenyl)-8-oxooctanoic acid (CAS 22811-92-3)
- Alice’s Ketone (CAS 37209-23-7)
- 8-(4-Methoxyphenyl)-1,4-dioxaspiro[4.5]Decan-8-ol (CAS 67019-51-6)
- Benzyl ((3S,4S)-4-methoxypyrrolidin-3-yl)(methyl)carbamate (CAS 2306252-41-3)
- Paclitaxel EP Impurity F (CAS 153083-53-5)
- Atazanavir impurity 19 (CAS 156474-21-4)
- Posaconazole Impurity 86 (CAS 170985-84-9)
- Tinidazole Impurity 14 (CAS CATO-C4X-193014)
- 6H-[1,2,3]Triazolo[4,5-d]pyrimidin-5-amine (CAS 10179-84-7)
- 2,5,7-Trimethylquinoline-4-carboxylic acid (CAS 436092-02-3)
- 4-(2-(3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)phenoxy)ethyl)morpholine (CAS 2096333-37-6)
- (4-Fluorothiophen-3-yl)(naphthalen-1-yl)methanol (CAS 1409026-12-5)
- N-(5-Bromo-3-cyclopropoxypyridin-2-yl)methanesulfonamide (CAS 1243386-31-3)
- Semaglutide impurity 261 (CAS CATO-C4X-2226261)
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