1-Cyclopropyl-6,8-difluoro-7-(3-((methylamino)methyl)pyrrolidin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid CAS 99735-00-9
| CAS No. | 99735-00-9 |
| Molecular Formula | C19H21F2N3O3 |
| Molecular Weight | 377.39 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO supplies 1-Cyclopropyl-6,8-difluoro-7-(3-((methylamino)methyl)pyrrolidin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (CAS 99735-00-9), a certified reference material (molecular formula C19H21F2N3O3, MW 377.39 g/mol) for analytical method development and quality control.
The molecular framework of 1-Cyclopropyl-6,8-difluoro-7-(3-((methylamino)methyl)pyrrolidin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (C19H21F2N3O3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H21F2N3O3 |
| Molecular Weight | 377.39 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Cyclopropyl Standards
- 1-Cyclopropyl-7-(4-ethylpiperazin-1-yl)-6,8-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (CAS 131776-00-6)
- 7-Cyclopropyl-2-thioxo-1-(o-tolyl)-5-(trifluoromethyl)-2,3-dihydropyrido[2,3-d]pyrimidin-4(1h)-one (CAS 938022-09-4)
- Methyl 3-cyclopropyl-1-(4-fluorophenyl)-6-(furan-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylate (CAS 1011396-86-3)
- N-Cyclopropyl-4-{[(4-methylphenyl)methyl]sulfanyl}-8-thia-3,5-diazatricyclo[7.4.0.0^{2,7}]trideca-1(13),2(7),3,5,9,11-hexaen-6-amine (CAS 478029-91-3)
- 9-Cyclopropyl-6,8-difluoro-7-(piperazin-1-yl)isothiazolo[5,4-b]quinoline-3,4(2H,9H)-dione (CAS 111279-49-3)
- Cyclopropyl 2-(2-methoxyphenyl)ethyl ketone (CAS 898774-25-9)
- Ethyl 2-(3-cyclopropyl-6-(furan-2-yl)-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetate (CAS 1018051-12-1)
- 2-(3-Cyclopropyl-6-(1,5-dimethyl-1h-pyrazol-4-yl)-4-(trifluoromethyl)-1h-pyrazolo[3,4-b]pyridin-1-yl)acetic acid (CAS 1006444-33-2)
Recommended Standards
- (R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(1H-pyrazol-1-yl)propanoic acid (CAS 948594-98-7)
- 2-((1-((2,6-Difluorophenyl)sulfonyl)azetidin-3-yl)sulfonyl)-1-methyl-1H-imidazole (CAS 2034261-78-2)
- (±)-Sanguinarine pseudoethanolate (CAS 28342-31-6)
- 2-((S)-2-((S)-1-((Benzyloxy)carbonyl)pyrrolidine-2-carboxamido)propanamido)acetic acid (CAS 23458-14-2)
- 2-((2-Fluorobenzyl)thio)ethan-1-ol (CAS 89040-05-1)
- 1-[2'-(Trifluoromethyl)[1,1'-biphenyl]-3-yl] ethanone (CAS 784142-96-7)
- 3-(Aminomethyl)-2-methylpyridine (CAS 58539-64-3)
- 2,4-Dichloro-6-(difluoromethyl)pyridine (CAS 1805252-95-2)
- Glycyrrhizin (CAS 103000-77-7)
- (Z)-Phenyl(pyridin-4-yl)methanone oxime (CAS 2147-26-4)
- (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-(sulfooxy)phenyl)propanoic acid (CAS 181952-24-9)
- 1-Acetyl-3-amino-1H-pyrazol-5(4H)-one (CAS 129027-73-2)
- 3-(3-Methoxyphenyl)morpholine (CAS 1017396-56-3)
- Semaglutide impurity 104(Fmoc-D-His-Aib) (CAS 2171211-18-8)
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